1例抗中性粒细胞胞浆抗体（p-ANCA）阳性的丙硫氧嘧啶诱发的坏疽性脓皮病
A Case of p-ANCA-Positive Propylthiouracil-Induced Pyoderma Gangrenosum.
作者信息
Seo Jong Won, Son Hyun Ho, Choi Joon Hee, Lee Sook Kyung
机构信息
Department of Dermatology, Maryknoll Medical Center, Busan, Korea.
出版信息
Ann Dermatol. 2010 Feb;22(1):48-50. doi: 10.5021/ad.2010.22.1.48. Epub 2010 Feb 28.
Abstract
Propylthiouracil is a common medication used in patients with hyperthyroidism; it can cause perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) in some patients with Graves' disease. This antibody has been associated with various forms of vasculitis and neutrophilic dermatosis. Herein, we report a patient who presented with cutaneous manifestations of pyoderma gangrenosum with simultaneous development of p-ANCAs during PTU therapy for Graves' disease.
摘要
丙硫氧嘧啶是治疗甲状腺功能亢进症患者常用的药物；在一些格雷夫斯病患者中，它可导致核周抗中性粒细胞胞浆抗体（p-ANCA）产生。这种抗体与多种形式的血管炎和嗜中性皮病有关。在此，我们报告1例在格雷夫斯病患者接受丙硫氧嘧啶治疗期间出现坏疽性脓皮病皮肤表现并同时出现p-ANCA的患者。
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