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1例抗中性粒细胞胞浆抗体（p-ANCA）阳性的丙硫氧嘧啶诱发的坏疽性脓皮病

A Case of p-ANCA-Positive Propylthiouracil-Induced Pyoderma Gangrenosum.

作者信息

Seo Jong Won, Son Hyun Ho, Choi Joon Hee, Lee Sook Kyung

机构信息

Department of Dermatology, Maryknoll Medical Center, Busan, Korea.

出版信息

Ann Dermatol. 2010 Feb;22(1):48-50. doi: 10.5021/ad.2010.22.1.48. Epub 2010 Feb 28.

DOI:10.5021/ad.2010.22.1.48
PMID:20548880
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2883396/
Abstract

Propylthiouracil is a common medication used in patients with hyperthyroidism; it can cause perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) in some patients with Graves' disease. This antibody has been associated with various forms of vasculitis and neutrophilic dermatosis. Herein, we report a patient who presented with cutaneous manifestations of pyoderma gangrenosum with simultaneous development of p-ANCAs during PTU therapy for Graves' disease.

摘要

丙硫氧嘧啶是治疗甲状腺功能亢进症患者常用的药物；在一些格雷夫斯病患者中，它可导致核周抗中性粒细胞胞浆抗体（p-ANCA）产生。这种抗体与多种形式的血管炎和嗜中性皮病有关。在此，我们报告1例在格雷夫斯病患者接受丙硫氧嘧啶治疗期间出现坏疽性脓皮病皮肤表现并同时出现p-ANCA的患者。

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Ann Dermatol. 2010 Feb;22(1):48-50. doi: 10.5021/ad.2010.22.1.48. Epub 2010 Feb 28.
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本文引用的文献

1
Antineutrophil cytoplasmic antibody-positive cutaneous leukocytoclastic vasculitis associated with propylthiouracil therapy.与丙硫氧嘧啶治疗相关的抗中性粒细胞胞浆抗体阳性皮肤白细胞破碎性血管炎
Arch Dermatol. 2006 Jul;142(7):879-80. doi: 10.1001/archderm.142.7.879.
2
ANCA positive propylthiouracil induced pyoderma gangrenosum.抗中性粒细胞胞浆抗体阳性的丙硫氧嘧啶诱发的坏疽性脓皮病。
J Endocrinol Invest. 2006 Jun;29(6):575-6. doi: 10.1007/BF03344152.
3
A case of propylthiouracil-induced pyoderma gangrenosum associated with antineutrophil cytoplasmic antibody.一例丙硫氧嘧啶诱发的坏疽性脓皮病伴抗中性粒细胞胞浆抗体
Dermatology. 2004;208(4):339-41. doi: 10.1159/000077844.
4
PTU-associated cutaneous vasculitis with ANCA anti-MPO and anti-PR3 antibodies.伴有抗髓过氧化物酶（ANCA anti-MPO）和抗蛋白酶3（anti-PR3）抗体的丙硫氧嘧啶相关皮肤血管炎
Neth J Med. 2003 Sep;61(9):296-9.
5
High prevalence of antineutrophil cytoplasmic antibody positivity in childhood onset Graves' disease treated with propylthiouracil.在接受丙硫氧嘧啶治疗的儿童期发病的格雷夫斯病中抗中性粒细胞胞浆抗体阳性的高患病率。
J Clin Endocrinol Metab. 2000 Nov;85(11):4270-3. doi: 10.1210/jcem.85.11.7000.
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Propylthiouracil-induced antineutrophil cytoplasm antibody-positive anaphylactoid purpura-like vasculitis--a case report.丙硫氧嘧啶诱发抗中性粒细胞胞浆抗体阳性的类过敏性紫癜样血管炎——病例报告
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Propylthiouracil-induced antineutrophil cytoplasmic antibodies in a patient with Graves' disease and a neutrophilic dermatosis.丙硫氧嘧啶诱发的格雷夫斯病合并嗜中性皮病患者的抗中性粒细胞胞浆抗体
Br J Dermatol. 1999 Nov;141(5):943-4. doi: 10.1046/j.1365-2133.1999.03186.x.
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Pyoderma gangrenosum with secondary pyarthrosis following propylthiouracil.丙硫氧嘧啶所致坏疽性脓皮病伴继发性化脓性关节炎
Australas J Dermatol. 1999 Aug;40(3):144-6. doi: 10.1046/j.1440-0960.1999.00346.x.
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Australas J Dermatol. 1998 May;39(2):96-9. doi: 10.1111/j.1440-0960.1998.tb01257.x.
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Case of propylthiouracil-induced vasculitis associated with anti-neutrophil cytoplasmic antibody (ANCA); review of literature.丙硫氧嘧啶诱发的血管炎合并抗中性粒细胞胞浆抗体（ANCA）病例；文献综述
Clin Nephrol. 1997 May;47(5):336-40.