Hospital Heliópolis (Heliopolis Hospital).
Braz J Otorhinolaryngol. 2010 Mar-Apr;76(2):225-30. doi: 10.1590/S1808-86942010000200013.
In early stage (I and II) laryngeal squamous cell carcinoma, both surgery and radiotherapy results in significant local and regional control. In advanced tumors (III and IV), radiotherapy alone has local-regional control rates of 32-43%.
To assess disease-free survival in SCC laryngeal carcinoma patients submitted to radiotherapy alone and/or associated with chemotherapy.
Retrospective study involving 84 cases of laryngeal SCC treated with radiotherapy or chemotherapy together with radiotherapy. Fifty-three cases were treated with intension to cure and 31 because of impossibility to resect the disease. As to clinical stage (CS), 12 were CS I, 15 II, 21 III and 5 IV. In the second group, 11 cases were EC III and 20 IV.
Mean age was 60 years, 84.5% were men. Fifty-eight (69.1%) cases had complete response and 26 (30.9%) had persistent or residual disease. Five-year disease-free survival was of 42.5%; 62.5% of the patients with organ preservation indication and 9.75 in the group of irressecable disease.
Disease-free survival of those patients submitted to radiotherapy because of laryngeal SCC was of 62.5%.
目的：评估单纯接受放疗和/或联合化疗的喉鳞状细胞癌患者的无病生存率。
材料和方法：回顾性研究纳入了 84 例接受放疗或联合化疗的喉鳞状细胞癌患者。53 例患者为治愈性治疗，31 例因疾病无法切除。根据临床分期（CS），12 例为 CS I，15 例为 CS II，21 例为 CS III，5 例为 CS IV。在第二组中，11 例为 EC III，20 例为 EC IV。
结果：平均年龄为 60 岁，84.5%为男性。58 例（69.1%）患者完全缓解，26 例（30.9%）患者存在持续或残留疾病。5 年无病生存率为 42.5%；有保留器官指征的患者中 62.5%，无法切除疾病组中为 9.75%。
结论：因喉鳞状细胞癌接受放疗的患者的无病生存率为 62.5%。
