从硝基烯烃到α-取代牛磺酸的多功能合成。

Versatile synthesis of α-substituted taurines from nitroolefins.

机构信息

State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology, People's Republic of China.

出版信息

Amino Acids. 2011 Jun;41(1):195-203. doi: 10.1007/s00726-010-0655-7. Epub 2010 Jun 12.

DOI:10.1007/s00726-010-0655-7

PMID:20549268

Abstract

A series of 1-substituted and 1,1-disubstituted taurines were synthesized from nitroolefins via the Michael addition with sodium ethylxanthate, oxidation with performic acid, and reduction with hydrogen in the presence of palladium on carbon powder. The current route is a versatile and salt-free method for synthesis of both aliphatic and aromatic 1-substituted and 1,1-disubstituted taurines.

摘要

一系列 1-取代和 1,1-二取代的牛磺酸通过亚乙基黄原酸钠与硝基烯烃的迈克尔加成、过甲酸氧化和钯碳粉存在下的氢气还原合成。该方法是一种通用且无盐的方法，可用于合成脂肪族和芳香族的 1-取代和 1,1-二取代的牛磺酸。