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Efficient synthesis of taurine and structurally diverse substituted taurines from aziridines.

作者信息

Hu Libo, Zhu Hui, Du Da-Ming, Xu Jiaxi

机构信息

Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.

出版信息

J Org Chem. 2007 Jun 8;72(12):4543-6. doi: 10.1021/jo070470c. Epub 2007 May 12.

DOI:10.1021/jo070470c
PMID:17497929
Abstract

Taurine and substituted taurines were synthesized efficiently from aziridines via ring-opening reaction with thioacetic acid, oxidation with performic acid, and hydrolysis in hydrochloric acid. The current method shows more benefit in purification and efficiency in the preparation of taurine and structurally diverse 2-substituted, 2,2-disubstituted, and 1,2-, 2,2-, and 2,N-alkylene taurines.

摘要

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