缺氧调节 microRNAs 在癌症中的作用。

The role of hypoxia regulated microRNAs in cancer.

机构信息

Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.

出版信息

Curr Top Microbiol Immunol. 2010;345:47-70. doi: 10.1007/82_2010_76.

DOI:10.1007/82_2010_76

PMID:20549470

Abstract

The molecular response of cancer cells to hypoxia is the focus of intense research. In the last decade, research into microRNAs (miRNAs), small RNAs which have a role in regulation of mRNA and translation, has grown exponentially. miR-210 has emerged as the predominant miRNA regulated by hypoxia. Elucidation of its targets points to a variety of roles for this, and other hypoxia-regulated miRNAs (HRMs), in tumour growth and survival. miR-210 expression correlates with poor survival in cancer patients, and shows promise for future use as a tumour marker or therapeutic agent. The role of miR-210 and other HRMs in cancer biology is the subject of this review.

摘要

癌细胞对缺氧的分子反应是目前研究的重点。在过去十年中，对 microRNAs（miRNAs）的研究——一种在 mRNA 和翻译调控中起作用的小 RNA——呈指数级增长。miR-210 是受缺氧调节的主要 miRNA。对其靶标的阐明表明，miR-210 和其他缺氧调节 miRNA（HRMs）在肿瘤生长和存活中具有多种作用。miR-210 的表达与癌症患者的不良预后相关，并且有望在未来用作肿瘤标志物或治疗剂。本文综述了 miR-210 和其他 HRMs 在癌症生物学中的作用。