Department of Pediatrics, Osaka University Graduate School of Medicine, Yamadaoka 2-2, Suita, Japan.
Int J Hematol. 2010 Jul;92(1):190-3. doi: 10.1007/s12185-010-0620-y. Epub 2010 Jun 15.
Anaplastic large cell lymphoma (ALCL) is chemosensitive, but recurrence is frequently observed. Allogeneic hematopoietic stem cell transplantation (HSCT) has recently been reported to be effective against recurrent disease, suggesting a graft-versus-lymphoma effect. We present a 3-year-old child with recurrent ALCL who underwent HSCT from an HLA-1-locus mismatched cord blood unit following reduced intensity conditioning with fludarabine, melphalan, and low-dose thoraco-abdominal irradiation. Engraftment was uneventful, but grade III acute graft-versus-host disease was observed. He is well and free of disease 25 months after HSCT, which implies that reduced intensity conditioning may allow a sufficient graft-versus-lymphoma effect against ALCL while lessening treatment-related toxicities.
间变大细胞淋巴瘤（ALCL）对化疗敏感，但常复发。异体造血干细胞移植（HSCT）最近被报道对复发病例有效，提示移植物抗淋巴瘤效应。我们报告了一例 3 岁儿童，在接受氟达拉滨、马法兰和低剂量胸腹照射的低强度预处理后，接受 HLA-1 位点不合的脐血单位的 HSCT，用于治疗复发性 ALCL。移植过程顺利，但出现 3 级急性移植物抗宿主病。HSCT 后 25 个月，他状况良好且无疾病，这表明低强度预处理可能在减轻治疗相关毒性的同时，对 ALCL 产生足够的移植物抗淋巴瘤效应。
