Graninger W B, Steinberg A D, Meron G, Smolen J S
2nd Department of Internal Medicine, University of Vienna, Austria.
Clin Exp Rheumatol. 1991 Jan-Feb;9(1):41-5.
In order to estimate the frequency of functionally relevant tubular damage in SLE patients we used the presence of overt renal tubular acidosis as an indicative parameter of interstitio-tubular damage in a cohort of 109 SLE patients who were well characterized for potential Sjögren's syndrome. Only two patients had overt renal tubular acidosis and interstitial nephritis without major glomerular involvement. Both patients, aside from having systemic lupus erythematosus, had a number of clinical features of concomitant primary Sjögren's syndrome. Based on the results obtained and the analyses of previously published cases, we put forward the hypothesis of simultaneous primary Sjögren's syndrome as the prevailing associative factor for the rare occurrence of isolated interstitial nephritis in SLE.
为了评估系统性红斑狼疮（SLE）患者功能性相关肾小管损伤的发生率，我们将明显肾小管酸中毒的存在作为肾小管间质损伤的指示参数，对一组109例SLE患者进行了研究，这些患者均具有潜在干燥综合征的典型特征。仅有两名患者出现明显的肾小管酸中毒和间质性肾炎，而无主要的肾小球受累。这两名患者除患有系统性红斑狼疮外，还具有一些原发性干燥综合征的临床特征。基于所获得的结果以及对既往已发表病例的分析，我们提出原发性干燥综合征同时存在是SLE中罕见孤立性间质性肾炎发生的主要关联因素这一假说。
