Department of Maternal-Fetal Medicine Hospital Clinic, University of Barcelona, Barcelona, Spain.
Ultrasound Obstet Gynecol. 2011 Feb;37(2):196-201. doi: 10.1002/uog.7722. Epub 2010 Jun 14.
To establish normal reference intervals of fetal regional brain blood perfusion using power Doppler ultrasound as measured by fractional moving blood volume (FMBV).
A cohort of consecutive singleton normally grown fetuses was selected including at least 12 fetuses for each completed week of gestation between 24 and 41 weeks. Cerebral blood perfusion was estimated using conventional power Doppler ultrasound in the following brain regions: frontal area, basal ganglia and posterior brain. Five consecutive good-quality images were recorded in each area and the region of interest was delineated offline. The FMBV was quantified as the average of all images and expressed as a percentage. Normal reference ranges were constructed by means of the LMS (lambda-mu-sigma) method.
A total of 230 fetuses were included. The median gestational age at evaluation and at delivery was 33.1 (range, 24.0-41.0) and 39.7 (range, 34.9-42.3) weeks, respectively. From 24 to 41 weeks' gestation, the mean FMBV increased from 13.21 to 14.97% in the frontal area, 11.17 to 14.86% in the basal ganglia and 4.83 to 6.70% in the posterior brain.
Normal data of fetal cerebral blood perfusion in the frontal area, basal ganglia and posterior brain are provided, which could be of clinical use in the assessment of fetal brain circulation.
利用彩色能量多普勒超声检测的血流分数（FMBV），建立胎儿脑区域性血流灌注的正常参考值范围。
选择连续的单胎正常生长胎儿队列，包括至少 12 例在 24-41 周每完成 1 周妊娠的胎儿。使用常规彩色能量多普勒超声估计脑血流灌注，在以下脑区测量：额区、基底节和后颅。在每个区域记录 5 个连续的高质量图像，并在离线时勾画感兴趣区。FMBV 作为所有图像的平均值进行量化，并表示为百分比。正常参考范围通过 LMS（lambda-mu-sigma）方法构建。
共纳入 230 例胎儿。评估时和分娩时的中位孕龄分别为 33.1（范围 24.0-41.0）和 39.7（范围 34.9-42.3）周。从 24 周到 41 周，额区的 FMBV 从 13.21%增加到 14.97%，基底节区从 11.17%增加到 14.86%，后颅区从 4.83%增加到 6.70%。
提供了胎儿额区、基底节区和后颅脑血流灌注的正常数据，这可能对评估胎儿脑循环具有临床应用价值。
