Bai Tao, Huang Jianfeng, Wang Wei
Peking University Eye Center, Peking University Third Hospital, Beijing, China.
Cutan Ocul Toxicol. 2010 Dec;29(4):247-53. doi: 10.3109/15569527.2010.492488. Epub 2010 Jun 16.
To compare the short-term effects of preserved and unpreserved topical levofloxacin on the ocular surface of preoperative patients with age-related cataracts.
This was a prospective, randomized, double-blind, parallel-group study. Patients who were going to undergo cataract surgery received either preserved topical levofloxacin (with 0.01% benzododecinium bromide [BOB]) or unpreserved topical levofloxacin instilled 4 times per day in a short-term course preoperatively. Enzyme-linked immunosorbent assay (ELISA) for MUC5AC, symptom scoring, tear film break-up time (BUT), corneal fluorescein staining, Schirmer I test, and conjunctival impression cytology were performed before and after the medication.
Sixty-two patients (62 eyes) who completed the final evaluation were included in the data analysis. Before the medication, there was no statistically significant difference (p > .05) between the 2 groups in terms of all the subjective symptoms and objective tests. After the medication, no statistically significant difference (p > .05) was observed in the scoring of each symptom between the 2 groups. With regard to BUT, corneal fluorescein staining, Schirmer I test, and conjunctival impression cytology, the 2 groups also demonstrated similar results and showed no significant difference (p > .05). In addition, the amounts of MUC5AC in the tear samples of patients with preexisting BUT ≤5 seconds were similar in the 2 groups and no significant difference was found (p > .05).
Regarding the short-term effects on the ocular surface of patients with age-related cataracts, no clinically and statistically significant differences were observed between topical levofloxacin preserved with BOB and its unpreserved counterpart.
比较保存型和未保存型局部用左氧氟沙星对年龄相关性白内障术前患者眼表的短期影响。
这是一项前瞻性、随机、双盲、平行组研究。拟行白内障手术的患者在术前短期内每天接受4次保存型局部用左氧氟沙星（含0.01%苯扎氯铵[BOB]）或未保存型局部用左氧氟沙星滴眼。在用药前后进行MUC5AC的酶联免疫吸附测定（ELISA）、症状评分、泪膜破裂时间（BUT）、角膜荧光素染色、Schirmer I试验和结膜印迹细胞学检查。
62例（62只眼）完成最终评估的患者纳入数据分析。用药前，两组在所有主观症状和客观检查方面均无统计学显著差异（p>0.05）。用药后，两组各症状评分均无统计学显著差异（p>0.05）。关于BUT、角膜荧光素染色、Schirmer I试验和结膜印迹细胞学检查，两组结果也相似，无显著差异（p>0.05）。此外，术前BUT≤5秒的患者泪液样本中MUC5AC的含量在两组中相似，未发现显著差异（p>0.05）。
对于年龄相关性白内障患者眼表的短期影响，含BOB的局部用左氧氟沙星与其未保存型在临床和统计学上均无显著差异。
