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利用西门子双胰高血糖素抗体和达科西玛兔抗人胰高血糖素多克隆抗体对血清和组织中胰高血糖素反应性进行差异比较揭示的十二指肠肠胰高血糖素瘤：一例报告

Duodenal enteroglucagonoma revealed by differential comparison of serum and tissue glucagon reactivity with Siemens' Double Glucagon Antibody and DakoCytomation's Polyclonal Rabbit Anti-Human Glucagon: a case report.

作者信息

Vanderlan Wesley B, Zhang Ziying, Abouljoud Marwan S

机构信息

Department of Surgery, Division of Transplant Surgery and Hepatobiliary Surgery, Henry Ford Hospital, West Grand Boulevard (CFP-2), Detroit, MI 48202, USA.

出版信息

J Med Case Rep. 2010 Jun 15;4:178. doi: 10.1186/1752-1947-4-178.

DOI:10.1186/1752-1947-4-178
PMID:20550685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2896376/
Abstract

INTRODUCTION

This case report demonstrates that the differential immunohistochemical reactivities of Siemens' Double Antibody Glucagon compared to DakoCytomation's Polyclonal Rabbit Anti-Human Glucagon allow for pathologic distinction of enteral versus pancreatic glucagonoma.

CASE PRESENTATION

A 64-year-old Caucasian man was diagnosed with a duodenal enteroglucagonoma following presentation with obstructive jaundice. He had a low serum glucagon level using Siemens' Double Antibody Glucagon, a clinical syndrome consistent with glucagon hypersecretion. A periampullary mass biopsy proved to be a neuroendocrine tumor, with positive immunohistochemical reactivity to DakoCytomation's Polyclonal Rabbit Anti-Human Glucagon.

CONCLUSIONS

Differential comparison of the immunohistochemical reactivities of Siemens' Double Antibody Glucagon and DakoCytomation's Polyclonal Rabbit Anti-Human Glucagon discerns enteroglucagon from pancreatic glucagon.

摘要

引言

本病例报告表明，与达科公司的兔抗人胰高血糖素多克隆抗体相比，西门子双抗体胰高血糖素的免疫组化反应性差异有助于区分肠道与胰腺来源的胰高血糖素瘤。

病例介绍

一名64岁的白种男性因出现梗阻性黄疸被诊断为十二指肠肠胰高血糖素瘤。使用西门子双抗体胰高血糖素检测时，其血清胰高血糖素水平较低，临床综合征与胰高血糖素分泌过多相符。壶腹周围肿物活检证实为神经内分泌肿瘤，对达科公司的兔抗人胰高血糖素多克隆抗体免疫组化反应呈阳性。

结论

比较西门子双抗体胰高血糖素和达科公司的兔抗人胰高血糖素多克隆抗体的免疫组化反应性差异，可区分肠胰高血糖素与胰腺胰高血糖素。

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本文引用的文献

1
Neuroendocrine tumors.神经内分泌肿瘤
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