Suppr超能文献

白光视频内镜与自发荧光内镜在高危人群腺瘤检测中的背靠背对比研究。

A back-to-back comparison of white light video endoscopy with autofluorescence endoscopy for adenoma detection in high-risk subjects.

机构信息

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, CE Rotterdam 3015, The Netherlands.

出版信息

Gut. 2010 Jun;59(6):785-93. doi: 10.1136/gut.2008.151589.

Abstract

OBJECTIVE

To compare the sensitivity of autofluorescence endoscopy (AFE) and white light video endoscopy (WLE) for the detection of colorectal adenomas in high-risk patients belonging to Lynch syndrome (LS) or familial colorectal cancer (CRC) families.

METHODS

This was a prospective single-centre study carried out in a tertiary referral centre. The subjects were 75 asymptomatic patients originating from LS or familial CRC families. Patients were examined with either WLE followed by AFE or AFE followed by WLE. Back-to-back colonoscopy was performed by two blinded endoscopists. All lesions were removed during the second endoscopic procedure. Lesions missed during the second procedure were identified and removed on third pass. The sensitivity calculations for colorectal adenomas were based on histology results. The main outcome measures were the difference in sensitivity between WLE and AFE for the detection of adenomas in patients with LS or familial CRC.

RESULTS

At least one adenoma was detected in 41 (55%) patients. WLE identified adenomas in 28/41 patients and AFE in 37/41 patients, corresponding to a 32% increase. In total 95 adenomas were detected, 65 by WLE and 87 by AFE, resulting in a significantly higher sensitivity of AFE compared with WLE (92% vs 68%; p=0.001). The additionally detected adenomas with AFE were significantly smaller than the adenomas detected by WLE (mean 3.0 mm vs 4.9 mm, p<0.01).

CONCLUSIONS

AFE improves the detection of colorectal adenomas in patients with LS or familial CRC. The results of this study suggest that AFE may be preferable for surveillance of these high-risk patients.

摘要

目的

比较自发荧光内镜(AFE)和白光视频内镜(WLE)检测林奇综合征(LS)或家族性结直肠癌(CRC)家族高危患者结直肠腺瘤的敏感性。

方法

这是一项在三级转诊中心进行的前瞻性单中心研究。研究对象为 75 名来自 LS 或家族性 CRC 家族的无症状患者。患者接受 WLE 后行 AFE 或 AFE 后行 WLE 检查。两名盲法内镜医生进行背对背结肠镜检查。所有病变均在第二次内镜检查中切除。在第二次检查中遗漏的病变在第三次通过时被识别并切除。结直肠腺瘤的敏感性计算基于组织学结果。主要观察指标是 LS 或家族性 CRC 患者中 WLE 和 AFE 检测腺瘤的敏感性差异。

结果

至少有一个腺瘤在 41 名(55%)患者中被发现。WLE 在 28/41 名患者中发现了腺瘤,AFE 在 37/41 名患者中发现了腺瘤,敏感性增加了 32%。共发现 95 个腺瘤,WLE 发现 65 个,AFE 发现 87 个,AFE 的敏感性明显高于 WLE(92%比 68%;p=0.001)。AFE 检测到的额外腺瘤明显小于 WLE 检测到的腺瘤(平均 3.0 毫米比 4.9 毫米,p<0.01)。

结论

AFE 提高了 LS 或家族性 CRC 患者结直肠腺瘤的检出率。本研究结果表明,AFE 可能更适合这些高危患者的监测。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验