de Sousa J B, Soares E G, Aprilli F
Department of Surgery, Orthopedics and Traumatology, University Hospital, Faculty of Medicine of Ribeirào Preto, University of São Paulo, Brazil.
Dis Colon Rectum. 1991 Jul;34(7):613-7. doi: 10.1007/BF02049903.
To study the possible effects of diclofenac sodium on intestinal anastomoses, 48 rabbits were submitted to surgery consisting of two single-layer ileal anastomoses performed with separate propylene 5-0 sutures. The animals were divided at random into two groups (test and control). The animals in the test group were given intramuscular injections of diclofenac sodium at the dose of 3 mg/kg body weight at 24-hour intervals, and the control animals were given injections of an identical amount of 0.9 percent saline. The animals were sacrificed on the 3rd, 7th, and 14th postoperative days for macroscopic evaluation of the peritoneal cavity and of the anastomoses, tensile strength measurement, hydroxyproline determination, and histopathologic examination. The following results were observed: anastomotic dehiscence followed by peritonitis and death in five test animals (20.83 percent) and no control animals; decreased anastomotic tensile strength on the 7th day in test animals (P less than 0.05); delayed acute inflammatory response and onset of fibroblast proliferation in the test group; and similar hydroxyproline levels in both groups. On the basis of the results obtained, we conclude that diclofenac sodium had a negative effect on intestinal anastomotic healing.
为研究双氯芬酸钠对肠吻合术的可能影响，48只兔子接受了手术，手术包括用单独的5-0聚丙烯缝线进行两次单层回肠吻合术。将动物随机分为两组（试验组和对照组）。试验组动物每隔24小时接受一次剂量为3mg/kg体重的双氯芬酸钠肌肉注射，对照组动物则注射等量的0.9%生理盐水。在术后第3天、第7天和第14天处死动物，以对腹腔和吻合口进行宏观评估、测量抗张强度、测定羟脯氨酸含量并进行组织病理学检查。观察到以下结果：5只试验组动物（20.83%）出现吻合口裂开，继而发生腹膜炎并死亡，而对照组动物未出现这种情况；试验组动物在第7天时吻合口抗张强度降低（P<0.05）；试验组出现急性炎症反应延迟和成纤维细胞增殖开始延迟；两组羟脯氨酸水平相似。根据所得结果，我们得出结论，双氯芬酸钠对肠吻合口愈合有负面影响。
