低氧诱导因子的甜蜜一面。
The sweet side of HIF.
机构信息
Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA.
出版信息
Kidney Int. 2010 Jul;78(1):10-3. doi: 10.1038/ki.2010.112.
Abstract
Hypoxia-inducible factors (HIFs) are oxygen-sensitive transcription factors that mediate cellular adaptation to hypoxia. Depending on the type of injury, activation of HIF signaling in renal cells may be renoprotective or promote fibrosis. Isoe and colleagues demonstrate that hyperglycemia activates HIF-1 in mesangial cells via carbohydrate response element binding protein (ChREBP), thus providing a novel link between alterations in systemic glucose homeostasis and HIF-regulated gene expression.
摘要
缺氧诱导因子 (HIFs) 是氧敏感转录因子，可介导细胞对缺氧的适应。根据损伤的类型，肾脏细胞中 HIF 信号的激活可能具有肾保护作用或促进纤维化。Isoe 及其同事证明，高血糖通过碳水化合物反应元件结合蛋白 (ChREBP) 激活系膜细胞中的 HIF-1，从而在系统葡萄糖稳态改变和 HIF 调节的基因表达之间提供了新的联系。
相似文献
1
The sweet side of HIF.低氧诱导因子的甜蜜一面。
Kidney Int. 2010 Jul;78(1):10-3. doi: 10.1038/ki.2010.112.
2
High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein.高葡萄糖通过碳水化合物反应元件结合蛋白激活肾小球系膜细胞中的 HIF-1 介导的信号转导。
Kidney Int. 2010 Jul;78(1):48-59. doi: 10.1038/ki.2010.99. Epub 2010 Apr 7.
3
Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia.维持引擎运转：缺氧诱导因子作为缺血期间心脏代谢和血管生成的关键调节因子
J Mol Med (Berl). 2007 Dec;85(12):1309-15. doi: 10.1007/s00109-007-0279-x. Epub 2007 Nov 20.
4
Whole genome profiling of short-term hypoxia induced genes and identification of HIF-1 binding sites provide insights into HIF-1 function in Caenorhabditis elegans.全基因组短时间缺氧诱导基因谱分析和 HIF-1 结合位点的鉴定为深入了解 HIF-1 在秀丽隐杆线虫中的功能提供了线索。
PLoS One. 2024 May 14;19(5):e0295094. doi: 10.1371/journal.pone.0295094. eCollection 2024.
5
[Roles and molecular mechanisms of hypoxia-inducible factors in renal cell carcinoma].[缺氧诱导因子在肾细胞癌中的作用及分子机制]
Yi Chuan. 2018 May 20;40(5):341-356. doi: 10.16288/j.yczz.17-406.
6
Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans.转录组分析描述了持续 HIF-1 过度激活在秀丽隐杆线虫中的后果。
PLoS One. 2024 Mar 22;19(3):e0295093. doi: 10.1371/journal.pone.0295093. eCollection 2024.
7
Hypoxia-inducible factor 3 biology: complexities and emerging themes.缺氧诱导因子3的生物学特性：复杂性与新出现的主题
Am J Physiol Cell Physiol. 2016 Feb 15;310(4):C260-9. doi: 10.1152/ajpcell.00315.2015. Epub 2015 Nov 11.
8
Obstructive Sleep Apnea Activates HIF-1 in a Hypoxia Dose-Dependent Manner in HCT116 Colorectal Carcinoma Cells.阻塞性睡眠呼吸暂停以缺氧剂量依赖的方式在 HCT116 结肠癌细胞中激活 HIF-1。
Int J Mol Sci. 2019 Jan 21;20(2):445. doi: 10.3390/ijms20020445.
9
Hypoxia and the HIF system in kidney disease.肾脏疾病中的缺氧与低氧诱导因子系统
J Mol Med (Berl). 2007 Dec;85(12):1325-30. doi: 10.1007/s00109-007-0278-y. Epub 2007 Nov 20.
10
Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells.缺氧诱导因子1（HIF-1）对抑制性PAS结构域蛋白基因表达的转录上调：缺氧细胞中HIF-1介导信号传导的负反馈调节回路。
J Biol Chem. 2007 May 11;282(19):14073-82. doi: 10.1074/jbc.M700732200. Epub 2007 Mar 12.
引用本文的文献
1
The prognostic outcome of 'type 2 diabetes mellitus and breast cancer' association pivots on hypoxia-hyperglycemia axis.“2型糖尿病与乳腺癌”关联的预后结果取决于缺氧-高血糖轴。
Cancer Cell Int. 2021 Jul 5;21(1):351. doi: 10.1186/s12935-021-02040-5.
2
Metformin: the updated protective property in kidney disease.二甲双胍：肾脏病方面的最新保护作用。
Aging (Albany NY). 2020 May 1;12(9):8742-8759. doi: 10.18632/aging.103095.
3
Circadian-Hypoxia Link and its Potential for Treatment of Cardiovascular Disease.昼夜节律-缺氧关联及其在心血管疾病治疗中的潜力。
Curr Pharm Des. 2019;25(10):1075-1090. doi: 10.2174/1381612825666190516081612.
4
2-Oxonanonoidal Antibiotic Actinolactomycin Inhibits Cancer Progression by Suppressing HIF-1α.2-氧代壬酮类抗生素 Actinolactomycin 通过抑制 HIF-1α 抑制癌症进展。
Cells. 2019 May 10;8(5):439. doi: 10.3390/cells8050439.
5
Hyperglycemia triggers HIPK2 protein degradation.高血糖会引发HIPK2蛋白降解。
Oncotarget. 2017 Jan 3;8(1):1190-1203. doi: 10.18632/oncotarget.13595.
6
Hexokinase 2 is a determinant of neuroblastoma metastasis.己糖激酶2是神经母细胞瘤转移的一个决定因素。
Br J Cancer. 2016 Mar 29;114(7):759-66. doi: 10.1038/bjc.2016.26. Epub 2016 Mar 17.
7
Resistance to Recombinant Human Erythropoietin Therapy in a Rat Model of Chronic Kidney Disease Associated Anemia.慢性肾脏病相关性贫血大鼠模型中对重组人促红细胞生成素治疗的抵抗性
Int J Mol Sci. 2015 Dec 25;17(1):28. doi: 10.3390/ijms17010028.
8
Hypoxia-induced retinal neovascularization in zebrafish embryos: a potential model of retinopathy of prematurity.斑马鱼胚胎中缺氧诱导的视网膜新生血管形成：一种早产儿视网膜病变的潜在模型。
PLoS One. 2015 May 15;10(5):e0126750. doi: 10.1371/journal.pone.0126750. eCollection 2015.
9
Neuroprotective and anti-inflammatory effects of the flavonoid-enriched fraction AF4 in a mouse model of hypoxic-ischemic brain injury.富含类黄酮的 AF4 分馏物对缺氧缺血性脑损伤小鼠模型的神经保护和抗炎作用。
PLoS One. 2012;7(12):e51324. doi: 10.1371/journal.pone.0051324. Epub 2012 Dec 12.
10
Sirtuins and renal diseases: relationship with aging and diabetic nephropathy.沉默调节蛋白与肾脏疾病：与衰老和糖尿病肾病的关系。
Clin Sci (Lond). 2013 Feb;124(3):153-64. doi: 10.1042/CS20120190.
本文引用的文献
1
High glucose activates HIF-1-mediated signal transduction in glomerular mesangial cells through a carbohydrate response element binding protein.高葡萄糖通过碳水化合物反应元件结合蛋白激活肾小球系膜细胞中的 HIF-1 介导的信号转导。
Kidney Int. 2010 Jul;78(1):48-59. doi: 10.1038/ki.2010.99. Epub 2010 Apr 7.
2
Human nephrosclerosis triggers a hypoxia-related glomerulopathy.人类肾硬化会引发与缺氧相关的肾小球病。
Am J Pathol. 2010 Feb;176(2):594-607. doi: 10.2353/ajpath.2010.090268. Epub 2009 Dec 17.
3
Carbohydrate-responsive element-binding protein (ChREBP) is a negative regulator of ARNT/HIF-1beta gene expression in pancreatic islet beta-cells.碳水化合物反应元件结合蛋白 (ChREBP) 是胰岛 β 细胞中 ARNT/HIF-1β 基因表达的负调控因子。
Diabetes. 2010 Jan;59(1):153-60. doi: 10.2337/db08-0868. Epub 2009 Oct 15.
4
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues.糖尿病组织中缺氧诱导的VEGF表达受损的分子基础。
Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13505-10. doi: 10.1073/pnas.0906670106. Epub 2009 Jul 28.
5
Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice.缺氧诱导因子-1α（HIF-1α）的稳定对于改善糖尿病小鼠的伤口愈合至关重要。
Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19426-31. doi: 10.1073/pnas.0805230105. Epub 2008 Dec 4.
6
Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics.慢性缺氧作为慢性肾脏病进展的一种机制：从假说到新型治疗方法
Kidney Int. 2008 Oct;74(7):867-72. doi: 10.1038/ki.2008.350. Epub 2008 Jul 16.
7
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.后生动物的氧感应：HIF羟化酶途径的核心作用。
Mol Cell. 2008 May 23;30(4):393-402. doi: 10.1016/j.molcel.2008.04.009.
8
Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice.降低细胞内超氧化物可纠正糖尿病小鼠缺血诱导的新生血管形成缺陷。
J Biol Chem. 2008 Apr 18;283(16):10930-8. doi: 10.1074/jbc.M707451200. Epub 2008 Jan 28.
9
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition.缺氧通过低氧诱导因子-1刺激上皮-间质转化在体内促进纤维生成。
J Clin Invest. 2007 Dec;117(12):3810-20. doi: 10.1172/JCI30487.
10
Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model.钴可改善肥胖型高血压2型糖尿病大鼠模型的肾损伤。
Nephrol Dial Transplant. 2008 Apr;23(4):1166-72. doi: 10.1093/ndt/gfm715. Epub 2007 Oct 28.
Zotero 插件