Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA.
Kidney Int. 2010 Jul;78(1):10-3. doi: 10.1038/ki.2010.112.
Hypoxia-inducible factors (HIFs) are oxygen-sensitive transcription factors that mediate cellular adaptation to hypoxia. Depending on the type of injury, activation of HIF signaling in renal cells may be renoprotective or promote fibrosis. Isoe and colleagues demonstrate that hyperglycemia activates HIF-1 in mesangial cells via carbohydrate response element binding protein (ChREBP), thus providing a novel link between alterations in systemic glucose homeostasis and HIF-regulated gene expression.
缺氧诱导因子 (HIFs) 是氧敏感转录因子，可介导细胞对缺氧的适应。根据损伤的类型，肾脏细胞中 HIF 信号的激活可能具有肾保护作用或促进纤维化。Isoe 及其同事证明，高血糖通过碳水化合物反应元件结合蛋白 (ChREBP) 激活系膜细胞中的 HIF-1，从而在系统葡萄糖稳态改变和 HIF 调节的基因表达之间提供了新的联系。
