普罗帕酮诱发的心律失常：机制是什么？

Proarrhythmia Induced by Propafenone: What is the Mechanism?

作者信息

Femenia Francisco, Palazzolo Jorge, Arce Mauricio, Arrieta Martin

机构信息

Unidad de Arritmias, Departamento de Cardiología, Hospital Espanol de Mendoza, Argentina.

出版信息

Indian Pacing Electrophysiol J. 2010 Jun 5;10(6):278-80.

PMID:20552063

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2880874/

Abstract

Propafenone, a Class IC antiarrhythmic drug, is an orally active sodium channel-blocking agent. It is effective in supraventricular tachyarrhythmias and is particularly useful in converting atrial fibrillation to sinus rhythm. In therapeutic doses, it may cause non-cardiac and cardiac toxicity, including proarrhythmia.

摘要

普罗帕酮是一种IC类抗心律失常药物，是一种口服有效的钠通道阻滞剂。它对室上性快速心律失常有效，尤其有助于将房颤转复为窦性心律。治疗剂量时，它可能导致非心脏和心脏毒性，包括促心律失常作用。