Israel C W
Klinik für Innere Medizin - Kardiologie & Angiologie, Evangelisches Krankenhaus Bielefeld, Burgsteig 13, 33617, Bielefeld, Deutschland.
Herzschrittmacherther Elektrophysiol. 2010 Jun;21(2):102-8. doi: 10.1007/s00399-010-0084-z.
ICD therapy represents a major advance in the treatment of patients with severely impaired left ventricular function after myocardial infarction. While an ICD implantation also remains a valuable option late (>5 years) after myocardial infarction, patients early after this event are at a competitive risk of arrhythmogenic and nonarrhythmogenic cardiac death. Prevention of sudden cardiac death in patients early after myocardial infarction, therefore, just converts the mode of death in a significant number of patients from sudden to nonsudden cardiac death (conversion theory). In patients with a left ventricular ejection fraction (LVEF) of < or =30% after myocardial infarction, implantation of the ICD should, therefore, be postponed to at least 30-40 days after the event. It is, however, not clear how the risk of sudden cardiac death should be approached during this post infarction phase. Similarly, it is not clear if patients with a reduced LVEF post infarction and additional specific risks (nonsustained ventricular tachycardia, atrial fibrillation, bundle branch block, etc.) beyond this single criterion may also benefit from ICD implantation and which risk factors may be relevant. In any case, ICD therapy should avoid right ventricular pacing and shock discharges whenever possible.
植入式心脏复律除颤器(ICD)治疗是心肌梗死后左心室功能严重受损患者治疗方面的一项重大进展。虽然ICD植入在心肌梗死后晚期(>5年)仍是一种有价值的选择,但在此事件后的早期患者面临心律失常性和非心律失常性心源性死亡的竞争风险。因此,预防心肌梗死后早期患者的心源性猝死,只是将大量患者的死亡方式从心源性猝死转变为非心源性猝死(转变理论)。对于心肌梗死后左心室射血分数(LVEF)≤30%的患者,ICD植入应因此推迟至事件发生后至少30 - 40天。然而,尚不清楚在此心肌梗死后阶段应如何处理心源性猝死风险。同样,尚不清楚心肌梗死后LVEF降低且除这一单一标准外还有其他特定风险(非持续性室性心动过速、心房颤动、束支传导阻滞等)的患者是否也能从ICD植入中获益,以及哪些风险因素可能相关。无论如何,ICD治疗应尽可能避免右心室起搏和电击。