Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, MA, USA.
J Eur Acad Dermatol Venereol. 2011 Feb;25(2):175-80. doi: 10.1111/j.1468-3083.2010.03736.x. Epub 2010 Jun 9.
Epidermolytic acanthoma (EA) is an uncommon cutaneous entity that typically presents as a solitary lesion, or, less commonly, as multiple or disseminated discrete lesions. It usually appears at or after middle-age, and has been reported in various locations including the face, trunk, extremities and genitalia. Histopathologically, EA shows epidermolytic hyperkeratosis (EHK) involving either the entire thickness of the epidermis or just the granular and upper spinous layers.
To describe the clinical and microscopic features of EA, we retrospectively reviewed all cases diagnosed as EA at the Skin Pathology Laboratory at Boston University between 1999 and 2009.
Solitary EA is more common in men (65%) and usually presents as a hyperkeratotic papule on the trunk (45%) or extremities (25%). Histopathologically, all cases of solitary EA showed the classical features of hyperkeratosis, acanthosis and EHK. Three architectural patterns were observed on scanning magnification: papillomatous (55%), cup-shaped (40%) and acanthotic (15%). Additional common features encountered included focal parakeratosis (85%), and a sparse to mild superficial perivascular lymphocytic infiltrate (90%).
This large case series of solitary EA reviews the clinical features of this entity and describes several new histological variants.
表皮松解性棘皮瘤（Epidermolytic acanthoma，EA）是一种罕见的皮肤实体瘤，通常表现为孤立性病变，或较少见为多发性或播散性离散性病变。它通常在中年或之后出现，并在各种部位报道，包括面部、躯干、四肢和生殖器。组织病理学上，EA 显示表皮松解性角化过度（Epidermolytic hyperkeratosis，EHK），累及整个表皮厚度或仅累及颗粒层和上层棘状层。
为了描述 EA 的临床和显微镜特征，我们回顾性地审查了 1999 年至 2009 年间在波士顿大学皮肤病理实验室诊断为 EA 的所有病例。
孤立性 EA 更常见于男性（65%），通常表现为躯干（45%）或四肢（25%）的角化过度丘疹。组织病理学上，所有孤立性 EA 病例均显示出典型的角化过度、棘皮症和 EHK 特征。在扫描放大倍数下观察到三种结构模式：乳头状（55%）、杯状（40%）和棘皮症（15%）。另外还发现了常见的特征，包括局灶性角化不全（85%）和稀疏至轻度浅层血管周围淋巴细胞浸润（90%）。
本孤立性 EA 的大型病例系列回顾了该实体的临床特征，并描述了几种新的组织学变异。
Zotero 插件