Fletcher J Wesley, Ramamurthi Arathi, Parekh Palak
Texas A&M Health Science Center College of Medicine, Temple, Texas (Fletcher, Ramamurthi, Parekh) and Department of Dermatology, Baylor Scott & White, Temple, Texas (Fletcher, Parekh).
Proc (Bayl Univ Med Cent). 2016 Apr;29(2):198-9. doi: 10.1080/08998280.2016.11929416.
Epidermolytic hyperkeratosis is a histological reaction pattern seen in a variety of disease processes, including epidermolytic ichthyosis, Vorner's epidermolytic palmoplantar keratoderma, epidermal nevus, and solitary epidermolytic acanthoma. Here we present the case of a 59-year-old woman with multiple asymptomatic papules on her vulva. Clinical differential diagnoses included condyloma acuminata, seborrheic keratoses, bowenoid papulosis, adnexal tumors, and papular acantholytic dyskeratosis. Shave biopsy revealed findings consistent with epidermolytic hyperkeratosis. This case represents an interesting presentation of focally disseminated vulvar epidermolytic acanthomas and highlights the importance of a biopsy in establishing this diagnosis.
表皮松解性角化过度是一种在多种疾病过程中出现的组织学反应模式，包括表皮松解性鱼鳞病、沃纳表皮松解性掌跖角化病、表皮痣和孤立性表皮松解性棘皮瘤。在此，我们报告一例59岁女性，其外阴出现多个无症状丘疹。临床鉴别诊断包括尖锐湿疣、脂溢性角化病、鲍温样丘疹病、附属器肿瘤和丘疹性棘层松解性角化不良。剃除活检显示的结果与表皮松解性角化过度一致。该病例是局灶性播散性外阴表皮松解性棘皮瘤的一个有趣表现，并强调了活检在确立该诊断中的重要性。
