调控 UV-C 光诱导 NF-κB 的早期和晚期相激活的差异信号通路。
Differential signaling circuits in regulation of ultraviolet C light-induced early- and late-phase activation of NF-κB.
机构信息
Department of Chemistry and Biochemistry, Edison Biotechnology Institute and Molecular and Cellular Biology Program, Ohio University, Athens, OH, USA.
出版信息
Photochem Photobiol. 2010 Sep-Oct;86(5):995-9. doi: 10.1111/j.1751-1097.2010.00767.x.
Ultraviolet C light (UVC) induces nuclear factor-kappa B (NF-κB) activation via a complex network. In the early phase (4-12 h) of irradiation, NF-κB activation is accompanied with IκBα reduction via a translation inhibition pathway. In the late phase of UVC-induced NF-κB activation (16-24 h), the IκBα depletion is a combined result of regulation at both transcriptional and translational levels. However, the NF-κB activation appears to be independent of the level of IκBα. In this review, we will discuss the multiple signaling circuits that regulate NF-κB activation during the early and late phases of UVC irradiation.
紫外线 C 光（UVC）通过复杂的网络诱导核因子-κB（NF-κB）激活。在照射的早期阶段（4-12 小时），NF-κB 的激活伴随着 IκBα 通过翻译抑制途径减少。在 UVC 诱导的 NF-κB 激活的晚期阶段（16-24 小时），IκBα 的耗竭是转录和翻译水平调节的综合结果。然而，NF-κB 的激活似乎与 IκBα 的水平无关。在这篇综述中，我们将讨论在 UVC 照射的早期和晚期阶段调节 NF-κB 激活的多个信号通路。
Zotero 插件