[硫酸亚铁与左甲状腺素药物相互作用导致的甲状腺功能减退]

[Hypothyroidism as the result of drug interaction between ferrous sulfate and levothyroxine].

作者信息

Fiaux E, Kadri K, Levasseur C, Le Guillou C, Chassagne P

机构信息

Service de médecine interne gériatrique, CHU de Rouen, 76031 Rouen cedex, France.

出版信息

Rev Med Interne. 2010 Oct;31(10):e4-5. doi: 10.1016/j.revmed.2009.09.038.

DOI:10.1016/j.revmed.2009.09.038

PMID:20554088

Abstract

We report a case of drug-drug interaction between ferrous sulfate and l-thyroxin. A 95-year-old woman treated successfully with l-thyroxin for many years received ferrous sulfate for anemia. This association led rapidly to recurrence of hypothyroidism with elevated serum than TSH level which completely resolved after withdrawal of iron therapy. Interaction was confirmed after both drugs were daily administrated separately without recurrence of hypothyroidism.

摘要

我们报告一例硫酸亚铁与左旋甲状腺素之间的药物相互作用病例。一名95岁女性多年来一直成功接受左旋甲状腺素治疗，因贫血接受了硫酸亚铁治疗。这种联合用药迅速导致甲状腺功能减退复发，血清促甲状腺激素（TSH）水平升高，在停用铁剂治疗后完全缓解。在分别每日服用这两种药物且未再出现甲状腺功能减退后，证实了药物相互作用。