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Evidence that the cycloheximide-sensitive site of adrenocorticotropic hormone action is in the mitochondrion. Changes in pregnenolone formation, cholesterol content, and the electron paramagnetic resonance spectra of cytochrome P-450.

作者信息

Simpson E R, McCarthy J L, Peterson J A

出版信息

J Biol Chem. 1978 May 10;253(9):3135-9.

PMID:205541
Abstract
摘要

相似文献

1
Evidence that the cycloheximide-sensitive site of adrenocorticotropic hormone action is in the mitochondrion. Changes in pregnenolone formation, cholesterol content, and the electron paramagnetic resonance spectra of cytochrome P-450.
J Biol Chem. 1978 May 10;253(9):3135-9.
2
Effect of ACTH on cholesterol side-chain cleavage in rat adrenal mitochondria.促肾上腺皮质激素对大鼠肾上腺线粒体胆固醇侧链裂解的影响。
Biochem Biophys Res Commun. 1972 Jan 31;46(2):483-90. doi: 10.1016/s0006-291x(72)80164-5.
3
Temperature dependence of cholesterol binding to cytochrome P-450scc of the rat adrenal. Effect of adrenocorticotropic hormone and cycloheximide.大鼠肾上腺中胆固醇与细胞色素P - 450scc结合的温度依赖性。促肾上腺皮质激素和环己酰亚胺的作用。
J Biol Chem. 1976 Nov 25;251(22):7120-6.
4
Adrenal mitochondrial cytochrome P-450 and cholesterol side chain cleavage activity. Differences in the response of the zona glomerulosa and zona fasciculata-reticularis to adrenocorticotropic hormone and its withdrawal.肾上腺线粒体细胞色素P - 450与胆固醇侧链裂解活性。球状带和束状带-网状带对促肾上腺皮质激素及其撤药反应的差异。
J Biol Chem. 1973 Nov 25;248(22):7860-4.
5
Control of substrate flux and adrenal cytochrome P-450.底物通量与肾上腺细胞色素P-450的调控
Ann N Y Acad Sci. 1973;212:290-306. doi: 10.1111/j.1749-6632.1973.tb47603.x.
6
The effect of ether anaesthesia stress on cholesterol-side-chain cleavage and cytochrome P450 in rat-adrenal mitochondria.乙醚麻醉应激对大鼠肾上腺线粒体胆固醇侧链裂解及细胞色素P450的影响。
Eur J Biochem. 1972 Jul 24;28(3):442-50. doi: 10.1111/j.1432-1033.1972.tb01931.x.
7
The mechanism of action of adrenocroticotropic hormone. The role of mitochondrial cholesterol accumulation in the regulation of steroidogenesis.
J Biol Chem. 1974 Jan 10;249(1):227-33.
8
Cytochrome P-450 of adrenal mitochondria. In vitro and in vivo changes in spin states.肾上腺线粒体的细胞色素P - 450。自旋状态的体外和体内变化。
J Biol Chem. 1975 Jun 25;250(12):4671-7.
9
Sterol carrier protein2. Identification of adrenal sterol carrier protein2 and site of action for mitochondrial cholesterol utilization.固醇载体蛋白2。肾上腺固醇载体蛋白2的鉴定及线粒体胆固醇利用的作用位点。
J Biol Chem. 1983 Oct 10;258(19):11731-7.
10
ACTH control of cholesterol side-chain cleavage at adrenal mitochondrial cytochrome P-450scc. Regulation of intramitochondrial cholesterol transfer.促肾上腺皮质激素对肾上腺线粒体细胞色素P-450scc胆固醇侧链裂解的控制。线粒体内胆固醇转运的调节。
Mol Cell Endocrinol. 1987 Sep;53(1-2):87-101. doi: 10.1016/0303-7207(87)90195-x.

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Detection of hCG Responsive Expression of the Steroidogenic Acute Regulatory Protein in Mouse Leydig Cells.小鼠睾丸间质细胞中类固醇生成急性调节蛋白的hCG反应性表达检测
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Roundup inhibits steroidogenesis by disrupting steroidogenic acute regulatory (StAR) protein expression.草甘膦通过破坏类固醇生成急性调节（StAR）蛋白的表达来抑制类固醇生成。
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Role of adrenal renin in the regulation of adrenal steroidogenesis by corticotropin.
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Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13.人类类固醇生成急性调节蛋白：在COS-1细胞中的功能活性、组织特异性表达以及结构基因定位于8p11.2和假基因定位于13号染色体。
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