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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

López de Pablo A L, Marco E J, Benito J M, Fraile M L, Sanz M L, Moreno M J, Conde M V

Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, Espãna.

Gen Pharmacol. 1991;22(2):353-8. doi: 10.1016/0306-3623(91)90463-g.

Platelets induced an endothelium-independent contraction in isolated cat middle cerebral artery under resting conditions. In precontracted segments they evoked an endothelium-dependent contraction followed by a relaxation. 2. The contraction induced by serotonin was unaffected by endothelium removal either in the absence or in the presence of a previous tone. 3. The contractile response to platelets and serotonin under resting tension was blocked in the same way by ketanserin, methysergide or cyproheptadine. 4. After adding the platelets, serotonin could be measured in the bath medium. 5. These results suggest that the endothelium plays a minor role in the contraction induced by platelets, which is partly due to serotonin release.

在静息条件下，血小板可使离体猫大脑中动脉产生非内皮依赖性收缩。在预收缩段，它们可引发内皮依赖性收缩，随后出现舒张。2. 无论有无先前的张力，5-羟色胺诱导的收缩均不受内皮去除的影响。3. 在静息张力下，对血小板和5-羟色胺的收缩反应可被酮色林、麦角新碱或赛庚啶以相同方式阻断。4. 添加血小板后，可在浴液中检测到5-羟色胺。5. 这些结果表明，内皮在血小板诱导的收缩中起次要作用，这部分归因于5-羟色胺的释放。

López de Pablo A L, Marco E J, Benito J M, Fraile M L, Sanz M L, Moreno M J, Conde M V

Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, Espãna.

Gen Pharmacol. 1991;22(2):353-8. doi: 10.1016/0306-3623(91)90463-g.

Platelets induced an endothelium-independent contraction in isolated cat middle cerebral artery under resting conditions. In precontracted segments they evoked an endothelium-dependent contraction followed by a relaxation. 2. The contraction induced by serotonin was unaffected by endothelium removal either in the absence or in the presence of a previous tone. 3. The contractile response to platelets and serotonin under resting tension was blocked in the same way by ketanserin, methysergide or cyproheptadine. 4. After adding the platelets, serotonin could be measured in the bath medium. 5. These results suggest that the endothelium plays a minor role in the contraction induced by platelets, which is partly due to serotonin release.

在静息条件下，血小板可使离体猫大脑中动脉产生非内皮依赖性收缩。在预收缩段，它们可引发内皮依赖性收缩，随后出现舒张。2. 无论有无先前的张力，5-羟色胺诱导的收缩均不受内皮去除的影响。3. 在静息张力下，对血小板和5-羟色胺的收缩反应可被酮色林、麦角新碱或赛庚啶以相同方式阻断。4. 添加血小板后，可在浴液中检测到5-羟色胺。5. 这些结果表明，内皮在血小板诱导的收缩中起次要作用，这部分归因于5-羟色胺的释放。