DDS, Departamento de Biociências, Av. Ana Costa, 95, Vila Mathias, Santos - SP, Brazil, 11060-001.
In Vivo. 2010 May-Jun;24(3):315-20.
The aim of this study was to investigate the expressions of cell cycle regulatory proteins such as p53, p16, p21, and Rb in squamous cell carcinoma of the oropharynx and their relation to histological differentiation, staging of disease, and prognosis.
Paraffin blocks from 21 primary tumors were obtained from archives of the Department of Pathology, Paulista Medical School, Federal University of Sao Paulo, UNIFESP/EPM. Immunohistochemistry was used to detect the expression of p53, p16, p21, and Rb by means of tissue microarrays.
Expression of p53, p21, p16 and Rb was not correlated with the stage of disease, histopathological grading or recurrence in squamous cell carcinoma of the oropharynx.
Taken together, our results suggest that p53, p16, p21 and Rb are not reliable biomarkers for prognosis of the tumor severity or recurrence in squamous cell carcinoma of the oropharynx as depicted by tissue microarrays and immunohistochemistry.
本研究旨在探讨细胞周期调控蛋白（如 p53、p16、p21 和 Rb）在口咽鳞状细胞癌中的表达及其与组织学分化、疾病分期和预后的关系。
从圣保罗联邦大学保罗医学院病理学系的档案中获得了 21 个原发性肿瘤的石蜡块。通过组织微阵列，免疫组织化学用于检测 p53、p16、p21 和 Rb 的表达。
p53、p21、p16 和 Rb 的表达与口咽鳞状细胞癌的疾病分期、组织病理学分级或复发无关。
总的来说，我们的结果表明，p53、p16、p21 和 Rb 不是组织微阵列和免疫组织化学显示的口咽鳞状细胞癌肿瘤严重程度或复发的可靠预后生物标志物。
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