College of Kinesiology, University of Saskatchewan, Saskatoon, SK S7N 5B2, Canada.
Appl Physiol Nutr Metab. 2010 Jun;35(3):235-43. doi: 10.1139/H10-011.
Previous fracture may predispose an individual to bone fragility because of impaired bone mineral accrual. The primary objective of the study was to investigate the influence of fractures sustained during childhood and (or) adolescence on total body (TB), lumbar spine (LS), femoral neck (FN), and total hip (TH) bone mineral content (BMC) in young adulthood. It was hypothesized that there would be lower TB, LS, FN, and TH BMC in participants who had sustained a pediatric fracture. Participant anthropometrics, physical activity, and BMC (measured with dual energy X-ray absorptiometry) were assessed longitudinally during childhood and adolescence (from 1991 to 1997), and again in young adulthood (2002 to 2006). Sex, adult height, adult lean mass, adult physical activity, and adolescent BMC adjusted TB, LS, FN, and TH BMC in young adulthood, for those who reported 1 or more fractures (n = 42), were compared with those who reported no fractures (n = 101). There were no significant differences (p > 0.05) in adjusted BMC between fracture and nonfracture groups at the TB, LS, FN, and TH sites in young adulthood. These results suggest that fractures sustained during childhood and adolescence may not interfere with bone mass in young adulthood at clinically relevant bone sites.
先前的骨折可能会使个体因骨矿物质积累受损而变得脆弱。本研究的主要目的是调查儿童期和（或）青春期发生的骨折对成年后全身（TB）、腰椎（LS）、股骨颈（FN）和全髋关节（TH）骨矿物质含量（BMC）的影响。研究假设，在发生过儿科骨折的参与者中，TB、LS、FN 和 TH 的 BMC 会较低。参与者的人体测量学、身体活动和 BMC（通过双能 X 射线吸收法测量）在儿童和青少年期（1991 年至 1997 年）进行了纵向评估，并在成年早期（2002 年至 2006 年）再次进行了评估。对于报告有 1 次或多次骨折的参与者（n=42），与未报告骨折的参与者（n=101）相比，报告 1 次或多次骨折的参与者的性别、成年身高、成年瘦体重、成年身体活动和青少年 BMC 调整了成年后 TB、LS、FN 和 TH 的 BMC。在 TB、LS、FN 和 TH 部位，骨折组和非骨折组之间的调整 BMC 没有显著差异（p＞0.05）。这些结果表明，儿童期和青春期发生的骨折可能不会在临床上相关的骨部位干扰成年后骨量。
