Thandrayen K, Norris S A, Micklesfield L K, Pettifor J M
MRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa,
Osteoporos Int. 2014 Feb;25(2):693-700. doi: 10.1007/s00198-013-2477-4. Epub 2013 Aug 14.
The associations of fracture prevalence and bone mass in adolescents with maternal fracture history and bone mass have not been investigated previously in South Africa. Maternal bone mass has a significant inverse association with their adolescents' fracture rates and bone mass across all ethnic groups.
Differences in fracture rates and bone mass between families and individuals of different ethnic origins may be due to differing lifestyles and/or genetic backgrounds. This study aimed to assess associations of fracture prevalence and bone mass in adolescents with maternal fracture history and bone mass, and sibling fracture history.
Data from 1,389 adolescent-biological mother pairs from the Birth to Twenty longitudinal study were obtained. Questionnaires were completed on adolescent fractures until 17/18 years of age and on sibling fractures. Biological mothers completed questionnaires on their own fractures prior to the age of 18 years. Anthropometric and bone mass data on adolescent-biological mother pairs were collected.
An adolescent's risk of lifetime fracture decreased with increasing maternal lumbar spine (LS) bone mineral content (BMC; 24 % reduction in fracture risk for every unit increase in maternal LS BMC Z-score) and increased if they were white, male, or had a sibling with a history of fracture. Adolescent height, weight, male gender, maternal bone area and BMC, and white ethnicity were positive predictors of adolescent bone mass. White adolescents and their mothers had a higher fracture prevalence (adolescents 42 %, mothers 31 %) compared to the black (adolescents 20 %, mothers 6 %) and mixed ancestry (adolescents 20 %, mothers 16 %) groups.
Maternal bone mass has a significant inverse association with their adolescent off-springs' fracture risk and bone mass. Furthermore, there is a strong familial component in fracture patterns among South African adolescents and their siblings.
南非此前尚未对有母亲骨折病史及骨量的青少年的骨折患病率与骨量之间的关联进行过研究。在所有种族群体中，母亲的骨量与她们青少年子女的骨折率和骨量之间存在显著的负相关。
不同种族家庭和个体之间骨折率和骨量的差异可能归因于不同的生活方式和/或遗传背景。本研究旨在评估有母亲骨折病史及骨量和兄弟姐妹骨折病史的青少年的骨折患病率与骨量之间的关联。
获取了来自“从出生到二十岁”纵向研究的1389对青少年-亲生母亲的数据。完成了关于青少年至17/18岁时骨折情况以及兄弟姐妹骨折情况的问卷调查。亲生母亲完成了关于她们18岁之前自身骨折情况的问卷调查。收集了青少年-亲生母亲对的人体测量和骨量数据。
青少年一生骨折的风险随着母亲腰椎（LS）骨矿物质含量（BMC）的增加而降低（母亲LS BMC Z评分每增加一个单位，骨折风险降低24%），如果青少年是白人、男性或有骨折病史的兄弟姐妹，则骨折风险增加。青少年的身高、体重、男性性别、母亲的骨面积和BMC以及白人种族是青少年骨量的正向预测因素。与黑人（青少年20%，母亲6%）和混血（青少年20%，母亲16%）群体相比，白人青少年及其母亲的骨折患病率更高（青少年42%，母亲31%）。
母亲的骨量与她们青少年后代的骨折风险和骨量之间存在显著的负相关。此外，南非青少年及其兄弟姐妹的骨折模式中存在很强的家族因素。
