Neurological soft signs as predictors of central nervous system involvement in HIV-1 infection.

There is increasing evidence in the literature to suggest that HIV-1 infection involves the central nervous system (CNS) as a result of its direct neurotropic properties. In order to find predictors of neurological dysfunction in HIV-1 infection 20 seropositive patients were studied. Data support the notion that neurological soft signs correlate with the stage of infection that may be considered an informative predictor of CNS involvement during the course of HIV-1 infection.