el-Nouty F D, Elbanna I M, Johnson H D
J Dairy Sci. 1978 Feb;61(2):189-96. doi: 10.3168/jds.s0022-0302(78)83577-2.
Four open, dry Holstein cows in the University of Missouri Climatic Laboratory were used to study the effect of adrenocorticotropic hormone administration on glucocorticoids and antidiuretic hormone of plasma in two reversal trials at thermoneutral (20 C, 50% relative humidity) and heat (33 C, 50% relative humidity) conditions. Average glucocorticoids (saline versus adrenocorticotropic hormone) at thermoneutral were 8.3 and 41.2 ng/ml while values for heat were 6.2 and 40.4 ng/ml. The effect of heat on glucocorticoids of plasma was not significant. Injection of adrenocorticotropic hormone under thermoneutrality and heat caused a marked increase in antidiuretic hormone within 5 min which lasted to 120 min. At thermoneutral average antidiuretic hormone levels (saline versus adrenocorticotropic hormone) were .5 and 1.9 pg/ml while values for heat were 1.8 and 3.6 pg/ml. Antidiuretic hormone concentrations under heat were higher than thermoneutral in cows injected with saline and andrenocorticotropic hormone. The fast response of antidiuretic hormone of plasma to exogenous adrenocorticotropic hormone suggests that adrenocorticotropic hormone might act directly at higher levels of the central nervous system causing release of antidiuretic hormone.
在密苏里大学气候实验室中，选用四头开放饲养的干奶荷斯坦奶牛，在热中性（20摄氏度，相对湿度50%）和炎热（33摄氏度，相对湿度50%）条件下进行了两项反转试验，以研究注射促肾上腺皮质激素对血浆中糖皮质激素和抗利尿激素的影响。热中性条件下，平均糖皮质激素水平（生理盐水组与促肾上腺皮质激素组）分别为8.3和41.2纳克/毫升，炎热条件下则为6.2和40.4纳克/毫升。炎热对血浆糖皮质激素的影响不显著。在热中性和炎热条件下注射促肾上腺皮质激素后，抗利尿激素在5分钟内显著增加，并持续至120分钟。热中性条件下，平均抗利尿激素水平（生理盐水组与促肾上腺皮质激素组）分别为0.5和1.9皮克/毫升，炎热条件下则为1.8和3.6皮克/毫升。注射生理盐水和促肾上腺皮质激素的奶牛在炎热条件下的抗利尿激素浓度高于热中性条件。血浆抗利尿激素对外源性促肾上腺皮质激素的快速反应表明，促肾上腺皮质激素可能直接作用于中枢神经系统的较高水平，从而导致抗利尿激素的释放。
