Rapti Z
Department of Mathematics, University of Illinois at Urbana-Champaign, Urbana, IL 61801-2975, USA.
Eur Phys J E Soft Matter. 2010 Jun;32(2):209-16. doi: 10.1140/epje/i2010-10618-y. Epub 2010 Jun 17.
We investigate a DNA model that takes into account stacking interactions with neighbors up to three bases away. The model is a generalization of the well-known Peyrard-Bishop (PB) model and is motivated by studies that suggest that nearest-neighbor models for base-pair interaction in a DNA chain might not be enough to capture the mechanism and dynamics of DNA base-pair opening. We study stationary solutions of the modified model and investigate their stability. A comparison with the PB model reveals that under a wide range of parameter values the main characteristics of the original model --such as the hyperbolicity of the equilibrium at the origin-- are preserved, but new types of stationary solutions emerge.