Division of Biology, Faculty of Science, Inönü University, Malatya, Turkey.
Eur Rev Med Pharmacol Sci. 2010 May;14(5):435-41.
The protective effect of melatonin on adriamycin (ADM)-induced cardiotoxicity was investigated in the rat heart. Melatonin is a pineal hormone with free radical scavenging activity on oxidants; therefore it may decrease the ADM-induced oxidative stress and cardiotoxicity so that therapeutic efficacy might be enhanced.
Wistar rats in 4 groups were treated with saline (control), melatonin (MEL), adriamycin (ADM) and melatonin plus adriamycin (MEL+ADM).
Adriamycin given at a single dose of 15 mg/kg significantly increased lipid peroxidation products as measured by thiobarbituric acid reactive substances (TBARS). Melatonin (5 mg/kg bw) given 2 days before and 7 days after ADM treatment reduced TBARS level. Adriamycin significantly reduced superoxide dismutase activity which was elevated by melatonin treatment. Additionally, ADM significantly increased catalase enzyme activity while melatonin normalized the ADM induced alteration in activity of catalase.
The combined use of ADM and melatonin reduces the threat of cardiomyopathy. Melatonin seems to hold promise as a therapeutic treatment and can be recommended as an adjunct in antitumor therapy as a safe and effective protection against acute ADM-induced cardiotoxicity.
研究褪黑素对阿霉素（ADM）诱导的心脏毒性的保护作用。褪黑素是一种松果腺激素，具有清除氧化剂自由基的活性; 因此，它可能降低 ADM 诱导的氧化应激和心脏毒性，从而增强治疗效果。
4 组 Wistar 大鼠分别给予生理盐水（对照组）、褪黑素（MEL）、阿霉素（ADM）和褪黑素加阿霉素（MEL+ADM）。
单次给予 15mg/kg 的阿霉素显着增加了丙二醛（TBARS）反应性物质测定的脂质过氧化产物。在 ADM 治疗前 2 天和后 7 天给予 5mg/kg bw 的褪黑素降低了 TBARS 水平。阿霉素显着降低了超氧化物歧化酶活性，而褪黑素治疗可升高该酶活性。此外，ADM 显着增加了过氧化氢酶酶活性，而褪黑素使 ADM 诱导的过氧化氢酶活性变化正常化。
ADM 和褪黑素的联合使用降低了心肌病的威胁。褪黑素似乎具有治疗潜力，并可作为抗肿瘤治疗的辅助手段，作为一种安全有效的急性 ADM 诱导性心脏毒性保护剂。
Zotero 插件