Gastroenterology Unit, BelColle Hospital, Viterbo, Italy.
Eur Rev Med Pharmacol Sci. 2010 May;14(5):455-63.
Inflammatory bowel disease (IBD) is an idiopathic condition of gastrointestinal tract whose pathogenesis results from the complex interaction of genetic susceptibility and environmental influences. Is well known how IBD patients have an increased risk of thrombosis.
To assess the frequency and characteristics of thromboembolic events (TEE) in IBD and the role of certain etiopathological factors in such thrombotic patients.
We report the case of a young woman affected by protein C deficiency, who during a clinical recurrence of ulcerative colitis (UC), developed a spontaneous right ventricular thrombus and pulmonary embolism. Then, we made a review of literature that documented thromboembolic events in IBD patients.
A search using the PubMed database identified 65 case reports documenting thromboembolic events in patients with known UC and 7 documenting thromboembolic events in known Crohn's disease.
The data of the literature confirm that IBD patients have an approximately three fold greater risk for developing a TEE compared with the general population. The risk for thrombosis correlates well with disease activity in Crohn's disease, and to lesser extent in ulcerative colitis.
炎症性肠病（IBD）是一种特发性胃肠道疾病，其发病机制是遗传易感性和环境影响的复杂相互作用。众所周知，IBD 患者有更高的血栓形成风险。
评估 IBD 患者中血栓栓塞事件（TEE）的频率和特征，以及某些病因病理因素在这些血栓形成患者中的作用。
我们报告了一例患有蛋白 C 缺乏症的年轻女性的病例，她在溃疡性结肠炎（UC）的临床复发期间，发生了自发性右心室血栓形成和肺栓塞。然后，我们对文献进行了回顾，其中记录了 IBD 患者的血栓栓塞事件。
使用 PubMed 数据库进行搜索，共确定了 65 例已知 UC 患者发生血栓栓塞事件的病例报告，以及 7 例已知克罗恩病患者发生血栓栓塞事件的病例报告。
文献数据证实，与普通人群相比，IBD 患者发生 TEE 的风险大约增加了三倍。血栓形成的风险与克罗恩病的疾病活动度密切相关，而在溃疡性结肠炎中则相关性较小。
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