定向反应中P3与自主神经成分之间的解剖学和功能关系。
The anatomical and functional relationship between the P3 and autonomic components of the orienting response.
作者信息
Nieuwenhuis Sander, De Geus Eco J, Aston-Jones Gary
机构信息
Leiden Institute for Brain and Cognition, Leiden University, Leiden, The NetherlandsInstitute of Psychology, Leiden University, Leiden, The NetherlandsDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The NetherlandsDepartment of Neurosciences, Medical University of South Carolina, Charleston, South Carolina.
出版信息
Psychophysiology. 2011 Feb;48(2):162-75. doi: 10.1111/j.1469-8986.2010.01057.x.
Many psychophysiologists have noted the striking similarities between the antecedent conditions for the P3 component of the event-related potential and the orienting response: both are typically elicited by salient, unexpected, novel, task-relevant, and other motivationally significant stimuli. Although the close coupling of the P3 and orienting response has been well documented, the neural basis and functional role of this relationship is still poorly understood. Here we propose that the simultaneous occurrence of the P3 and autonomic components of the orienting response reflects the co-activation of the locus coeruleus-norepinephrine system and the peripheral sympathetic nervous system by their common major afferent: the rostral ventrolateral medulla, a key sympathoexcitatory region. A comparison of the functional significance of the locus coeruleus-norepinephrine system and the peripheral sympathetic nervous system suggests that the P3 and orienting response reflect complementary cognitive and physical contributions to the mobilization for action following motivationally significant stimuli.
许多心理生理学家已经注意到，事件相关电位的P3成分的先行条件与定向反应之间存在惊人的相似之处：两者通常都由显著的、意外的、新颖的、与任务相关的以及其他具有动机意义的刺激所引发。尽管P3与定向反应之间的紧密关联已有充分记录，但这种关系的神经基础和功能作用仍知之甚少。在此，我们提出，P3与定向反应的自主成分同时出现反映了蓝斑-去甲肾上腺素系统和外周交感神经系统被它们共同的主要传入神经——延髓头端腹外侧，一个关键的交感兴奋区域——共同激活。对蓝斑-去甲肾上腺素系统和外周交感神经系统功能意义的比较表明，P3和定向反应反映了在具有动机意义的刺激后，对行动动员的互补性认知和生理贡献。
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