Liu Jingyu, Kiehl Kent A, Pearlson Godfrey, Perrone-Bizzozero Nora I, Eichele Tom, Calhoun Vince D
The Mind Research Network, Albuquerque, NM 87131, USA.
Neuroimage. 2009 Jul 1;46(3):809-16. doi: 10.1016/j.neuroimage.2009.02.045. Epub 2009 Mar 10.
Processing of novel and target stimuli in the auditory target detection or 'oddball' task encompasses the chronometry of perception, attention and working memory and is reflected in scalp recorded event-related potentials (ERPs). A variety of ERP components related to target and novelty processing have been described and extensively studied, and linked to deficits of cognitive processing. However, little is known about associations of genotypes with ERP endophenotypes. Here we sought to elucidate the genetic underpinnings of auditory oddball ERP components using a novel data analysis technique. A parallel independent component analysis of the electrophysiology and single nucleotide polymorphism (SNP) data was used to extract relations between patterns of ERP components and SNP associations purely based on an analysis incorporating higher order statistics. The method allows for broader associations of genotypes with phenotypes than traditional hypothesis-driven univariate correlational analyses. We show that target detection and processing of novel stimuli are both associated with a shared cluster of genes linked to the adrenergic and dopaminergic pathways. These results provide evidence of genetic influences on normal patterns of ERP generation during auditory target detection and novelty processing at the SNP association level.
在听觉目标检测或“异常球”任务中，对新异刺激和目标刺激的处理涉及感知、注意力和工作记忆的计时，并反映在头皮记录的事件相关电位（ERP）中。已经描述并广泛研究了多种与目标和新异处理相关的ERP成分，并将其与认知处理缺陷联系起来。然而，关于基因型与ERP内表型的关联却知之甚少。在此，我们试图使用一种新颖的数据分析技术来阐明听觉异常球ERP成分的遗传基础。对电生理和单核苷酸多态性（SNP）数据进行并行独立成分分析，以纯粹基于包含高阶统计量的分析来提取ERP成分模式与SNP关联之间的关系。与传统的假设驱动单变量相关分析相比，该方法允许基因型与表型有更广泛的关联。我们表明，目标检测和新异刺激的处理均与与肾上腺素能和多巴胺能途径相关的一组共同基因簇有关。这些结果为在SNP关联水平上，遗传因素对听觉目标检测和新异处理过程中ERP正常生成模式的影响提供了证据。
