Rosen-Bronson S, Jaraquemada D
Department of Pediatrics, Georgetown University School of Medicine, Washington, DC.
Hum Immunol. 1991 Mar;30(3):215-21. doi: 10.1016/0198-8859(91)90037-a.
The HLA-DR2 haplotype encodes two highly polymorphic DR molecules, DR2a and DR2b. Because little is known regarding the relative immunogenicity of different HLA-DR molecules, we have studied the T-cell recognition of DR2a and DR2b molecules from the DRw15, Dw2 haplotype. A series of DR2-specific alloreactive T-cell clones were analyzed with murine L-cell transfectants expressing either the DR2a or the DR2b molecules as stimulator cells in proliferation assays. Somewhat surprisingly, both DR2a and DR2b were capable of stimulating DR2-specific T-cell clones with equal magnitude and similar frequency. In addition, DR2a and DR2b are functionally distinct, that is, no clone was identified which was stimulated by both DR2a and DR2b molecules.
HLA-DR2单倍型编码两种高度多态的DR分子，即DR2a和DR2b。由于对于不同HLA-DR分子的相对免疫原性了解甚少，我们研究了来自DRw15、Dw2单倍型的DR2a和DR2b分子的T细胞识别情况。在增殖试验中，用表达DR2a或DR2b分子的鼠L细胞转染体作为刺激细胞，分析了一系列DR2特异性同种异体反应性T细胞克隆。有点令人惊讶的是，DR2a和DR2b都能够以相同的强度和相似的频率刺激DR2特异性T细胞克隆。此外，DR2a和DR2b在功能上是不同的，也就是说，没有鉴定出同时被DR2a和DR2b分子刺激的克隆。
