Department of Hospital Nursing, Xijing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China.
Jpn J Clin Oncol. 2010 Nov;40(11):1046-52. doi: 10.1093/jjco/hyq098. Epub 2010 Jun 17.
To investigate the possible role of CD147 and vascular endothelial growth factor in progression and prognosis of acute myeloid leukemia.
Immunohistochemical staining was performed to detect the expression of CD147 and vascular endothelial growth factor in paraffin-embedded sections from 62 bone marrow biopsies obtained from an equal number of patients with newly diagnosed acute myeloid leukemia.
CD147 and vascular endothelial growth factor expression in the bone marrow of acute myeloid leukemia patients were significantly higher than those in normal controls (both P < 0.001). Expression of them was significantly increased in patients with a high degree of microvessel density compared with those with a low degree (CD147: P = 0.009; vascular endothelial growth factor: P = 0.01) and correlated well with bone marrow microvessel density (CD147: P = 0.01; vascular endothelial growth factor: P = 0.02). In addition, higher levels of CD147 and vascular endothelial growth factor were also found in acute myeloid leukemia patients with an unfavorable karyotype compared with those with intermediate and favorable karyotypes (both P = 0.01). Moreover, the expression of CD147 was significantly correlated with that of vascular endothelial growth factor (P < 0.001). Furthermore, the co-expression of CD147 and vascular endothelial growth factor in the bone marrow indicated a poor prognosis in acute myeloid leukemia and was an independent prognostic factor for overall survival by multivariate analysis.
Our data show for the first time that the co-expression of CD147 and vascular endothelial growth factor may indicate a poor prognosis in acute myeloid leukemia and may be a highly sensitive marker for predicting the clinical outcome of patients.
探讨 CD147 和血管内皮生长因子在急性髓系白血病进展和预后中的可能作用。
采用免疫组织化学染色法检测 62 例初诊急性髓系白血病患者骨髓石蜡包埋切片中 CD147 和血管内皮生长因子的表达。
急性髓系白血病患者骨髓中 CD147 和血管内皮生长因子的表达明显高于正常对照组（均 P < 0.001）。高微血管密度患者的表达明显高于低微血管密度患者（CD147：P = 0.009；血管内皮生长因子：P = 0.01），与骨髓微血管密度密切相关（CD147：P = 0.01；血管内皮生长因子：P = 0.02）。此外，与中危和低危核型相比，高危核型急性髓系白血病患者的 CD147 和血管内皮生长因子水平也较高（均 P = 0.01）。此外，CD147 的表达与血管内皮生长因子的表达显著相关（P < 0.001）。此外，骨髓中 CD147 和血管内皮生长因子的共表达表明急性髓系白血病预后不良，且多因素分析显示其为总生存的独立预后因素。
我们的数据首次表明，CD147 和血管内皮生长因子的共表达可能预示着急性髓系白血病预后不良，并且可能是预测患者临床结局的高度敏感标志物。
