Department of Maternal-Fetal Medicine/ICGON, Hospital Clínic, University of Barcelona, c/Sabino de Arana 1, Barcelona, Spain.
Fetal Diagn Ther. 2010;28(2):114-6. doi: 10.1159/000314038. Epub 2010 Jun 19.
Placenta previa (PP), with a frequency of 5-7% in the second trimester, is considered one of the most important causes of obstetric hemorrhage. Surgical curettage is the classically recommended method to perform a midtrimester termination of pregnancy (TOP) in the presence of PP. Recent clinical reports suggest that induction of delivery is possible in these cases, but no information on mifepristone-misoprostol regimen is available. We present 2 cases of mifepristone-misoprostol midtrimester TOP with a diagnosis of complete PP. In both cases, a preinduction feticide was performed. Neither of the 2 cases presented a significant maternal bleeding. This report is relevant considering that this regimen is the most widely used and generally reported as the safest and most effective medical midtrimester TOP method.
前置胎盘（PP）在妊娠中期的发生率为 5-7%，是产科出血的最重要原因之一。对于存在前置胎盘的情况下，妊娠中期终止妊娠（TOP），传统上推荐采用刮宫术。最近的临床报告表明，在这些情况下可以诱导分娩，但关于米非司酮-米索前列醇方案的信息尚不清楚。我们报告了 2 例经诊断为完全性前置胎盘的米非司酮-米索前列醇妊娠中期 TOP 病例。在这 2 例病例中，均进行了诱导前胎儿死亡。这 2 例病例均未出现明显的母体出血。考虑到该方案是最广泛使用的方案，并且通常被报道为最安全、最有效的药物性妊娠中期 TOP 方法，因此本报告具有重要意义。
