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Adverse interaction of fluoxetine and cyproheptadine in two patients with bulimia nervosa.

作者信息

Goldbloom D S, Kennedy S H

机构信息

Toronto Hospital, Department of Psychiatry, University of Toronto, Ontario, Canada.

出版信息

J Clin Psychiatry. 1991 Jun;52(6):261-2.

PMID:2055898
Abstract

The sexual side effect of anorgasmia has been reported with a variety of antidepressants, including fluoxetine. Cyproheptadine has been used to counteract these side effects. The authors report two cases of bulimia nervosa in which the serotonin antagonist effect of cyproheptadine appeared to cancel out the therapeutic benefits of the serotonin-specific uptake inhibitor fluoxetine.

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