临床局部晚期N0M0前列腺癌根治性前列腺切除术的疗效

Outcomes of radical prostatectomy in clinically locally advanced N0M0 prostate cancer.

作者信息

Mearini Luigi, Zucchi Alessandro, Costantini Elisabetta, Bini Vittorio, Nunzi Elisabetta, Porena Massimo

机构信息

Urology Department, University of Perugia, Perugia, Italy.

出版信息

Urol Int. 2010;85(2):166-72. doi: 10.1159/000316944. Epub 2010 Jun 18.

DOI:10.1159/000316944

PMID:20558980

Abstract

INTRODUCTION

Radical prostatectomy (RP) in patients with locally advanced (cT3) prostate cancer (PCa) is considered an optional therapy.

AIM

To evaluate outcomes of surgery for cT3 disease and to compare results with those of patients treated for cT1-T2 PCa.

PATIENTS AND METHODS

Data of 74 consecutive patients with cT3 N0M0 PCa who underwent RP were compared to those of 425 consecutive unselected patients who underwent surgery for cT1-T2 N0M0 disease.

RESULTS

cT3: The pathological report showed a pathological downstaging in 16.3% of cases. Continence rate was 65.5%, potency rate was 38.8%, 5-year PSA-free survival was 61.9%, 5-year cancer-specific survival was 95.2%. cT1-T2: The pathological report showed a clinical downstaging in 39.1%. Continence rate was 70.8%, potency rate was 56.2%, 5-year PSA-free survival was 67.4%, 5-year cancer-specific survival was 96.0%.

CONCLUSIONS

cT3 PCa presents challenges for the uro-oncologist since standard treatment is still under debate. RP in well-informed patients is a procedure with acceptable morbidity and should be at least a first part of a multimodality approach.

摘要

引言

对于局部晚期（cT3）前列腺癌（PCa）患者，根治性前列腺切除术（RP）被认为是一种可选择的治疗方法。

目的

评估cT3期疾病的手术效果，并与cT1 - T2期PCa患者的治疗结果进行比较。

患者与方法

将74例连续接受RP的cT3 N0M0 PCa患者的数据与425例连续接受cT1 - T2 N0M0疾病手术的未选择患者的数据进行比较。

结果

cT3期：病理报告显示16.3%的病例病理分期下降。控尿率为65.5%，性功能保留率为38.8%，5年无PSA生存率为61.9%，5年癌症特异性生存率为95.2%。cT1 - T2期：病理报告显示39.1%的病例临床分期下降。控尿率为70.8%，性功能保留率为56.2%，5年无PSA生存率为67.4%，5年癌症特异性生存率为96.0%。