Aytaç Selin, Gümrük Fatma, Cetin Mualla, Tuncer Murat, Yetgin Sevgi
Department of Pediatric Hematology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
Turk J Pediatr. 2010 Mar-Apr;52(2):211-4.
Chemotherapy-induced acral erythema (CIAE) with bullous formation is an uncommon complication in children. We describe herein a child who developed CIAE with bullous formation following high-dose methotrexate and cytarabine for relapsed acute lymphoblastic leukemia. The rash completely resolved within two weeks of the appearance without any specific treatment. CIAE may develop in children with hematological malignancies as a complication of pediatric chemotherapeutic regimens, and pediatricians should be aware of this phenomenon despite its rarity.
化疗引起的伴有水疱形成的手足红斑（CIAE）在儿童中是一种罕见的并发症。我们在此描述一名儿童，他在接受大剂量甲氨蝶呤和阿糖胞苷治疗复发性急性淋巴细胞白血病后出现了伴有水疱形成的CIAE。皮疹在出现后的两周内完全消退，未进行任何特殊治疗。CIAE可能作为儿科化疗方案的并发症在血液系统恶性肿瘤患儿中发生，尽管这种情况罕见，但儿科医生应了解这一现象。
