Doris N. Grandon Center for Health Economics and Outcomes Research, Jefferson School of Population Health, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Value Health. 2010 Sep-Oct;13(6):720-5. doi: 10.1111/j.1524-4733.2010.00739.x. Epub 2010 Jun 7.
The study aims to apply willingness-to-pay (WTP) values derived from the literature to inform decision-makers of the cost-effectiveness of the Tailored Activity Program (TAP), an intervention proven to reduce caregiver burden.
TAP and other caregiver interventions employ an individual perspective and non-quality-adjusted life-year (QALY) outcome measure where the primary objective is to determine caregiver burden from an individual perspective. Therefore, standard cost/QALY thresholds are not appropriate. To identify relevant WTP values, we searched for studies that: 1) were published in the past 5 years and used contingent valuation methodology to identify WTP; 2) assessed WTP for a dementia-related intervention requiring out-of-pocket expenditure; and 3) asked caregivers their WTP for an outcome related to reducing caregiver burden. Three studies were identified utilizing four WTP values. We also assessed potential financial savings that caregivers could achieve from purchasing TAP. To assess the probability of TAP being cost-effective, we built a Monte Carlo simulation to test the four WTP values applied to two TAP outcome measures: reduction in caregiver hours "on duty;" and "doing things."
For outcome measure "on duty," WTP varied between $1.06/hour and $4.58/hour. For outcome measure "doing things," WTP varied between $2.21/hour and $9.57/hour. Applying the four identified WTP values from the literature to TAP outcomes resulted in TAP cost-effectiveness varying between 50% and 80% for both outcome measures.
When WTP data are not collected prospectively or conventional metrics cannot be applied, retrospectively assessing literature-derived WTP may be acceptable for informing decision-makers of potential cost-effectiveness of a proven program. Application of WTP to TAP shows potential cost-effectiveness that can be expected under the tested WTP scenarios.
本研究旨在应用文献中得出的意愿支付(WTP)值,为决策者提供经证实可降低照料者负担的个体化活动计划(TAP)干预措施的成本效益信息。
TAP 和其他照料者干预措施采用个体视角和非质量调整生命年(QALY)结果测量方法,其主要目标是从个体视角确定照料者负担。因此,标准的成本/QALY 阈值并不适用。为了确定相关的 WTP 值,我们搜索了以下研究:1)发表于过去 5 年,使用意愿评估法来确定 WTP;2)评估与需要自付费用的痴呆相关干预措施的 WTP;3)询问照料者他们对减轻照料者负担相关结果的 WTP。利用四项 WTP 值,我们确定了三项研究。我们还评估了照料者购买 TAP 可能实现的潜在经济节省。为了评估 TAP 是否具有成本效益,我们构建了蒙特卡罗模拟来测试四种 WTP 值在两种 TAP 结果测量中的应用:减少照料者“值班”时间和“做事”时间。
对于“值班”结果测量,WTP 值在 1.06 美元/小时至 4.58 美元/小时之间变化。对于“做事”结果测量,WTP 值在 2.21 美元/小时至 9.57 美元/小时之间变化。将文献中确定的四项 WTP 值应用于 TAP 结果,导致 TAP 在两种结果测量中成本效益在 50%到 80%之间变化。
当无法前瞻性地收集 WTP 数据或无法应用常规指标时,回顾性评估文献中得出的 WTP 值可能有助于决策者了解已证实方案的潜在成本效益。将 WTP 应用于 TAP 显示出在测试的 WTP 情景下可能具有成本效益。