Wang Mei-Fang, Yang Lin-Hua, Yang Xiao-Ling, Zhang Rui-Juan, Hou Li-Hong, Liu Xiu-E
Department of Hematology, The Second Hospital, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Jun;18(3):753-6.
This study was purposed to investigate the correlation of deep vein thrombosis (DVT) with C-reactive protein (CRP), fibrinogen (Fg), coagulation factor VIII (FVIII:C), coagulation factor IX (FIX:C) and to explore the effect of inflammation and coagulation as well as their interaction in DVT and its mechanism. 59 patients with DVT undergoing selective venous ultrasonography and 26 healthy individuals as controls were enrolled in this study. The plasma level of CRP was detected by immunoturbidimetry, FVIII:C, FIX:C levels were determined by a one-stage assay and fibrinogen level was measured by full-automatic biochemical apparatus. The results showed that the mean levels of plasma CRP, Fg, FVIII:C and FIX:C were significantly higher in deep vein thrombosis group than that in controls [CRP (2.67 +/- 0.91) vs (0.14 +/- 0.08) mg/dl; Fg (4.73 +/- 1.36) vs (2.79 +/- 0.66)g/L; FVIII:C (126.71 +/- 28.10) vs (81.35 +/- 20.77)%; FIX:C (81.01 +/- 23.60) vs (70.71 +/- 11.3)%] (p < 0.01), and the level of plasma CRP was strongly correlated with Fg, FVIII:C and FIX:C (r(s) = 0.432, 0.571 and 0.544, p < 0.01). It is concluded that the DVT and inflammation are closely related, increased level of plasma CRP may be a predictor of DVT. Increased plasma levels of Fg, FVIII:C and FIX:C all are important risk factors to DVT. Interaction between inflammation and coagulation promote the incidence of DVT, which may be one of DVT pathogenesis.
本研究旨在探讨深静脉血栓形成(DVT)与C反应蛋白(CRP)、纤维蛋白原(Fg)、凝血因子VIII(FVIII:C)、凝血因子IX(FIX:C)的相关性,探讨炎症与凝血及其相互作用在DVT中的作用及机制。本研究纳入59例行选择性静脉超声检查的DVT患者及26例健康个体作为对照。采用免疫比浊法检测血浆CRP水平,采用一期法测定FVIII:C、FIX:C水平,采用全自动生化分析仪检测纤维蛋白原水平。结果显示,深静脉血栓形成组血浆CRP、Fg、FVIII:C和FIX:C的平均水平显著高于对照组[CRP(2.67±0.91)对(0.14±0.08)mg/dl;Fg(4.73±1.36)对(2.79±0.66)g/L;FVIII:C(126.71±28.10)对(81.35±20.77)%;FIX:C(81.01±23.60)对(70.71±11.3)%](p<0.01),血浆CRP水平与Fg、FVIII:C和FIX:C密切相关(r(s)=0.432、0.571和0.544,p<0.01)。结论:DVT与炎症密切相关,血浆CRP水平升高可能是DVT的预测指标。血浆Fg、FVIII:C和FIX:C水平升高均是DVT的重要危险因素。炎症与凝血之间的相互作用促进了DVT的发生,这可能是DVT发病机制之一。