Guan Zhiyu
Department of Tramotology and Orthopedics, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550001, P.R. China.
Exp Ther Med. 2020 Mar;19(3):2113-2118. doi: 10.3892/etm.2019.8365. Epub 2019 Dec 20.
Changes in the expression of serum chemokine CXC ligand 13 (CXCL13) and interleukin-6 (IL-6), and the relationship with lower limb vein thrombus were explored. A total of 128 patients undergoing hip replacement in The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine from May 2017 to June 2019 were selected, and the patients suffering from lower limb vein thrombus were enrolled as group A and other patients not suffering from it were enrolled as group B. Enzyme-linked immuno-sorbent assay was employed to determine the levels of serum chemokine CXCL13 and IL-6, and receiver operating characteristic curves of serum chemokine CXCL13 and IL-6 levels in diagnosing restenosis after surgery were drawn. Pearson's correlation coefficient was adopted to analyze the correlation between serum chemokine CXCL13 and IL-6, and the logistic regression analysis to analyze the risk factors affecting hip replacement in patients. The levels of serum CXCL13 and IL-6 in group A were significantly higher than those in group B (both P<0.001). The specificity and sensitivity of serum CXCL13 level in diagnosis of lower limb vein thrombus after hip replacement were 61.76 and 80.00%, respectively, and those of serum IL-6 level in diagnosis were 70.59 and 66.67%, respectively. Serum CXCL13 level was positively correlated with serum IL-6 level (P<0.001), and age, body mass index (BMI), CXCL13 level and IL-6 level of the patients were independent risk factors affecting the efficacy of hip replacement. Serum CXCL13 level and serum IL-6 level can be used as biological indexes for prediction of early lower limb vein thrombus after hip replacement, and logistic regression analysis revealed that the age of the patients, BMI, diabetes history, hyperlipidemia history, hypertension history, CXCL13 level and IL-6 level are independent risk factors affecting the efficacy of hip replacement.
探讨血清趋化因子CXC配体13（CXCL13）和白细胞介素-6（IL-6）表达变化及其与下肢静脉血栓的关系。选取2017年5月至2019年6月在贵州中医药大学第一附属医院行髋关节置换术的128例患者，将发生下肢静脉血栓的患者纳入A组，未发生下肢静脉血栓的患者纳入B组。采用酶联免疫吸附测定法测定血清趋化因子CXCL13和IL-6水平，并绘制血清趋化因子CXCL13和IL-6水平诊断术后再狭窄的受试者工作特征曲线。采用Pearson相关系数分析血清趋化因子CXCL13与IL-6的相关性，采用Logistic回归分析影响患者髋关节置换疗效的危险因素。A组血清CXCL13和IL-6水平显著高于B组（均P<0.001）。血清CXCL13水平诊断髋关节置换术后下肢静脉血栓的特异性和敏感性分别为61.76%和80.00%，血清IL-6水平诊断的特异性和敏感性分别为70.59%和66.67%。血清CXCL13水平与血清IL-6水平呈正相关（P<0.001），患者年龄、体重指数（BMI）、CXCL13水平和IL-6水平是影响髋关节置换疗效的独立危险因素。血清CXCL13水平和血清IL-6水平可作为预测髋关节置换术后早期下肢静脉血栓形成的生物学指标，Logistic回归分析显示患者年龄、BMI、糖尿病史、高脂血症史、高血压史、CXCL13水平和IL-6水平是影响髋关节置换疗效的独立危险因素。
