Kohno H
Department of Orthopaedic Surgery, Yamanashi Medical College, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1991 Apr;65(4):207-15.
Further therapeutical investigations are necessary to obtain a satisfactory survival rate of patients by improving the conventional methods of the treatment of osteosarcoma. Our working hypothesis is that an estrogenic hormonal influence is available for the effective treatment of osteosarcoma. An attempt was made to clarify this idea using experimentally induced hamster osteosarcoma. Male and female Syrian golden hamsters were used. Small amounts of minced tumor pieces were transplanted into hamsters subcutaneously. The levels of the circulating estradiol (E2) and alkaline phosphatase (ALPase) in blood were determined after the transplantation. An estrogen receptor (ER) on tumor cells was also demonstrated. Hamsters with an increased level of serum E2 were likely to have a smaller size of primary tumors and a smaller number of nodes in the lung metastasis. These tumor cells were successfully shown to be positive for ER stain. This suggests that E2 treatment may possibly control the osteosarcoma-condition.
为了通过改进骨肉瘤的传统治疗方法来获得令人满意的患者生存率，进一步的治疗研究是必要的。我们的工作假设是，雌激素激素影响可用于骨肉瘤的有效治疗。我们试图通过实验诱导的仓鼠骨肉瘤来阐明这一观点。使用了雄性和雌性叙利亚金仓鼠。将少量切碎的肿瘤块皮下移植到仓鼠体内。移植后测定血液中循环雌二醇（E2）和碱性磷酸酶（ALPase）的水平。还证实了肿瘤细胞上存在雌激素受体（ER）。血清E2水平升高的仓鼠可能原发性肿瘤较小，肺转移结节数量较少。这些肿瘤细胞经ER染色成功显示为阳性。这表明E2治疗可能控制骨肉瘤病情。
