IA 类 PI3K 的调节亚基。

Regulatory subunits of class IA PI3K.

机构信息

Department of Molecular Biology & Biochemistry, Institute for Immunology, University of California, Irvine, CA, 92697-3900, USA.

出版信息

Curr Top Microbiol Immunol. 2010;346:225-44. doi: 10.1007/82_2010_39.

DOI:10.1007/82_2010_39

PMID:20563711

Abstract

All class I PI3K enzymes are obligate heterodimers, consisting of a catalytic subunit tightly bound to a regulatory subunit. The regulatory subunit influences the subcellular location, binding partners, and activity of the catalytic subunit. Regulatory subunits also possess adaptor functions in cellular signaling, which are largely independent of their role in regulating PI3K activity. This chapter reviews the structure and function of PI3K regulatory subunits, focusing on the class IA subgroup.

摘要

所有 I 类 PI3K 酶都是必需的异源二聚体，由紧密结合的催化亚基和调节亚基组成。调节亚基影响催化亚基的亚细胞定位、结合伙伴和活性。调节亚基在细胞信号转导中还具有衔接功能，这些功能在很大程度上与其在调节 PI3K 活性中的作用无关。本章回顾了 PI3K 调节亚基的结构和功能，重点介绍了 IA 亚组。