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[Studies on ouinolone antibiotics. II. Synthesis and antibacterial activity of 7-aminoalkoxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3 -carbo xylic acids and their derivatives].

作者信息

Yoshida T, Yamamoto Y, Yagi N, Takahasi Y, Yasuda S, Katoh H, Itoh Y

机构信息

Central Research Laboratories, Hokuriku Seiyaku Co., Ltd., Fukui, Japan.

出版信息

Yakugaku Zasshi. 1991 Jan;111(1):19-31. doi: 10.1248/yakushi1947.111.1_19.

DOI:10.1248/yakushi1947.111.1_19
PMID:2056441
Abstract

7-Aminoalkoxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3- carboxylic acid and their derivatives were synthesized and their antibacterial activities were evaluated. Among them, compounds having an alkyl group at alpha-position of the amino group were found to have in vitro and in vivo antibacterial activity comparable to that of ciprofloxacin. Structure-activity relationship of these compounds was also stated.

摘要

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