Huang Zhen-bu, Nie Han-qiu
Wenzhou Medical College, Wenzhou Medicine Hospital, Wenzhou, China.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010 Apr;26(4):371-3.
To investigate the relationship between the micro-lymphatic vessel density (LMVD) and invasion and metastasis in gastric carcinoma.
The expression of LYVE-1 in 52 cases of gastric carcinoma was detected by immunohistochemical SP method, by which the LMVD was calculated.
The lymphangiogenesis was shown in peritumoral tissue in gastric carcinoma. LMVD of gastric carcinoma was higher than that of normal gastric tissue (P<0.05). LMVD with lymphatic metastasis was higher than that without lymphatic metastasis (P<0.05); LMVD with big tumor (diameter >5 cm) was higher than that with small tumor (diameter <5 cm) (P<0.05); LMVD with serosal invasion was higher than that without serosal invasion (P<0.05).
LMVD is closely related to lymph node metastasis, tumor size and invasive depth, which is helpful to determine the prognosis of gastric cancer and treatment program evaluation.
探讨胃癌组织中微淋巴管密度（LMVD）与侵袭转移的关系。
采用免疫组织化学SP法检测52例胃癌组织中LYVE-1的表达，并计算LMVD。
胃癌组织周边可见淋巴管生成。胃癌组织的LMVD高于正常胃组织（P<0.05）；有淋巴结转移的胃癌组织LMVD高于无淋巴结转移者（P<0.05）；肿瘤直径>5 cm的胃癌组织LMVD高于肿瘤直径<5 cm者（P<0.05）；有浆膜侵犯的胃癌组织LMVD高于无浆膜侵犯者（P<0.05）。
LMVD与胃癌淋巴结转移、肿瘤大小及浸润深度密切相关，对判断胃癌预后及治疗方案的评估有一定帮助。
