Kulikov A S, Sorokin V S, Lubnin A Iu
Anesteziol Reanimatol. 2010 Jan-Feb(1):6-10.
The study was undertaken to evaluate the efficiency and safety of oral premedication in children with intracranial neurosurgical pathology before elective interventions in two modalities: a combination of midasolam 0.5 mg/kg body weight and ketamine 3 mg/kg (Group 1; n = 80) and midasolam 0.75 mg/kg only (Group 2; n = 20). The study was conducted in 100 children aged 2 to 10 years. Medical and sweet syrups were used to dilute the agents. In Groups 1 and 2, an effective anxiolytic effect was achieved in 92 and 80%, respectively. A sedative effect was also more pronounced in Group 1 children. The mean duration of effect achievement was 20 minutes. There were no serious complications when both regimens were used. Both oral premedication modes are considered to be effective and must be used for premedication in children with neurosurgical diseases.
咪达唑仑0.5mg/kg体重与氯胺酮3mg/kg联合使用（第1组；n = 80）以及仅使用咪达唑仑0.75mg/kg（第2组；n = 20）。该研究在100名2至10岁的儿童中进行。使用医用糖浆和甜糖浆来稀释药物。在第1组和第2组中，分别有92%和80%的儿童获得了有效的抗焦虑效果。第1组儿童的镇静效果也更明显。达到效果的平均持续时间为20分钟。两种方案使用时均未出现严重并发症。两种口服术前用药方式均被认为是有效的，并且必须用于患有神经外科疾病儿童的术前用药。
