Chichakhov D A, Gordeev V I, Aleksandrovich Iu S
Anesteziol Reanimatol. 2010 Jan-Feb(1):17-9.
A prospective randomized study was conducted to evaluate the efficiency of two intravenous anesthesia modes in children during traumatological operations. Anesthesia induction and maintenance were carried out via intravenous injection of ketamine (2 mg/kg/hr) and propofol (4 mg/kg/hr) in Group 1 children and via that of propofol (4 mg/kg/ hr) and fentanyl (3 microg/kg/hr) in Group 2. The mean duration of operations was 43.6 +/- 27.8 and 29.6 +/- 17.8 min in Groups 1 and 2, respectively. No complications were observed in Group 1; short-term apnea was seen in 2 (7.6%) children during initial anesthesia in Group 2. The children of this group were also found to have lower respiration rate. Both drug combinations were ascertained to provide a sufficient anesthesia depth in non-intubated, spontaneously breathing children, but the use of a combination of propofol + ketamine (Group 1) produced no negative impact on hemodynamics and external respiration parameters, which allowed this combination to be recommended for short-term surgical interventions.
进行了一项前瞻性随机研究，以评估两种静脉麻醉方式在儿童创伤手术中的效果。第一组儿童通过静脉注射氯胺酮（2毫克/千克/小时）和丙泊酚（4毫克/千克/小时）进行麻醉诱导和维持，第二组儿童通过静脉注射丙泊酚（4毫克/千克/小时）和芬太尼（3微克/千克/小时）进行麻醉诱导和维持。第一组和第二组的平均手术时间分别为43.6±27.8分钟和29.6±17.8分钟。第一组未观察到并发症；第二组有2名（7.6%）儿童在初始麻醉期间出现短期呼吸暂停。该组儿童的呼吸频率也较低。已确定两种药物组合均可为未插管、自主呼吸的儿童提供足够的麻醉深度，但丙泊酚+氯胺酮组合（第一组）对血流动力学和外部呼吸参数没有负面影响，因此该组合推荐用于短期手术干预。
