Department of Physiological Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, USA.
Respir Res. 2010 Jun 18;11(1):80. doi: 10.1186/1465-9921-11-80.
Mammalian lung development is a complex biological process, which is temporally and spatially regulated by growth factors, hormones, and extracellular matrix proteins. Abnormal changes of these molecules often lead to impaired lung development, and thus pulmonary diseases. Epithelial-mesenchymal interactions are crucial for fetal lung development. This paper reviews two interconnected pathways, pleiotrophin and Wnt/beta-catenin, which are involved in fibroblast and epithelial cell communication during fetal lung development.
哺乳动物肺发育是一个复杂的生物学过程，受到生长因子、激素和细胞外基质蛋白的时空调节。这些分子的异常变化常导致肺发育受损，进而引发肺部疾病。上皮-间充质相互作用对胎儿肺发育至关重要。本文综述了两个相互关联的途径，即多效蛋白和 Wnt/β-连环蛋白，它们参与了胎儿肺发育过程中成纤维细胞和上皮细胞的通讯。
