Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-5-7 Asahimachi Abeno-ku, Osaka 545-8585, Japan.
J Exp Clin Cancer Res. 2010 Jun 21;29(1):79. doi: 10.1186/1756-9966-29-79.
Connexin26 (Cx26) is one of the connexins (Cxs) family members which form gap junction channels. Cx26 is considered to be a tumor suppressor gene. However, recent studies revealed that over expression of Cx26 is associated with a poor prognosis in several human cancers. This study investigated the correlation between Cx26 expression and the clinicopathological features and P53 expression in colorectal cancer.
One hundred and fifty-three patients who underwent a curative resection were studied. Tissue samples were investigated by immunohistochemical staining using antibodies for Cx26 and P53. Moreover, apoptotic cells were detected by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) staining.
Cx26 expression was found in 83 cases (54.2%) and P53 expression in 71 cases (46.4%). A correlation was observed between the Cx26 expression and recurrence, histology, and p53 expression (P < 0.05). Cx26 positive tumors had significantly longer survival than Cx26 negative tumors (P < 0.05). A multivariate Cox analysis demonstrated that Cx26 expression was an independent prognostic factor (P < 0.05). However, no significant correlation was observed between Cx26 and AI.
This study suggests that Cx26 expression is an independent prognostic factor in patients that undergo a curative resection of colorectal cancer.
连接蛋白 26（Cx26）是间隙连接通道形成的连接蛋白（Cxs）家族成员之一。Cx26 被认为是一种肿瘤抑制基因。然而，最近的研究表明，Cx26 的过表达与几种人类癌症的预后不良有关。本研究探讨了 Cx26 表达与结直肠癌临床病理特征和 P53 表达之间的相关性。
研究了 153 例接受根治性切除术的患者。使用针对 Cx26 和 P53 的抗体通过免疫组织化学染色研究组织样本。此外，通过末端脱氧核苷酸转移酶介导的 dUTP-生物素缺口末端标记（TUNEL）染色检测凋亡细胞。
发现 83 例（54.2%）存在 Cx26 表达，71 例（46.4%）存在 P53 表达。Cx26 表达与复发、组织学和 p53 表达之间存在相关性（P < 0.05）。Cx26 阳性肿瘤的生存时间明显长于 Cx26 阴性肿瘤（P < 0.05）。多变量 Cox 分析表明，Cx26 表达是独立的预后因素（P < 0.05）。然而，Cx26 与 AI 之间没有显著相关性。
本研究表明，Cx26 表达是接受结直肠癌根治性切除术患者的独立预后因素。
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