Department of Orthopaedic and Trauma Surgery, University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany.
BMC Musculoskelet Disord. 2010 Jun 21;11:128. doi: 10.1186/1471-2474-11-128.
Osteoarthritis (OA) is the most common degenerative arthropathy. Load-bearing joints such as knee and hip are more often affected than spine or hands. The prevalence of gonarthrosis is generally higher than that of coxarthrosis.Because no cure for OA exists, the main emphasis of therapy is analgesic treatment through either mobility or medication. Non-pharmacologic treatment is the first step, followed by the addition of analgesic medication, and ultimately by surgery.The goal of non-pharmacologic and non-invasive therapy is to improve neuromuscular function, which in turn both prevents formation of and delays progression of OA. A modification of conventional physiotherapy, whole body vibration has been successfully employed for several years. Since its introduction, this therapy is in wide use at our facility not only for gonarthrosis, but also coxarthrosis and other diseases leading to muscular imbalance.
METHODS/DESIGN: This study is a randomized, therapy-controlled trial in a primary care setting at a university hospital. Patients presenting to our outpatient clinic with initial symptoms of gonarthrosis will be assessed against inclusion and exclusion criteria. After patient consent, 6 weeks of treatment will ensue. During the six weeks of treatment, patients will receive one of two treatments, conventional physiotherapy or whole-body-vibration exercises of one hour three times a week. Follow-up examinations will be performed immediately after treatment and after another 6 and 20 weeks, for a total study duration of 6 months. 20 patients will be included in each therapy group.Outcome measurements will include objective analysis of motion and ambulation as well as examinations of balance and isokinetic force. The Western Ontario and McMaster Universities Arthritis Index and SF-12 scores, the patients' overall status, and clinical examinations of the affected joint will be carried out.
As new physiotherapy techniques develop for the treatment of OA, it is important to investigate the effectiveness of competing strategies. With this study, not only patient-based scores, but also objective assessments will be used to quantify patient-derived benefits of therapy.
Deutsches Register Klinischer Studien (DRKS) DRKS00000415Clinicaltrials.gov NCT01037972EudraCT 2009-017617-29.
骨关节炎（OA）是最常见的退行性关节病。承重关节如膝和髋比脊柱或手更容易受到影响。膝骨关节炎的患病率普遍高于髋骨关节炎。由于 OA 无法治愈，治疗的主要重点是通过运动或药物进行镇痛治疗。非药物治疗是第一步，然后是添加镇痛药物，最后是手术。非药物和非侵入性治疗的目标是改善神经肌肉功能，这反过来又可以预防和延缓 OA 的形成和进展。传统物理疗法的一种改良，全身振动已经成功应用了多年。自引入以来，这种疗法在我们的机构中得到了广泛的应用，不仅用于膝骨关节炎，还用于髋骨关节炎和其他导致肌肉失衡的疾病。
方法/设计：这是一项在大学医院的初级保健环境中进行的随机、治疗对照试验。在我们的门诊就诊时出现膝骨关节炎初始症状的患者将根据纳入和排除标准进行评估。在获得患者同意后，将进行为期 6 周的治疗。在 6 周的治疗期间，患者将接受两种治疗方法之一，即常规物理疗法或每周三次、每次 1 小时的全身振动运动。治疗结束后立即进行随访检查，然后在 6 周和 20 周后再次进行检查，总研究时间为 6 个月。每个治疗组将纳入 20 名患者。
结果测量将包括运动和步行的客观分析以及平衡和等速肌力的检查。将进行 Western Ontario 和 McMaster 大学关节炎指数和 SF-12 评分、患者整体状况以及受影响关节的临床检查。
随着治疗 OA 的新物理治疗技术的发展，研究竞争策略的有效性非常重要。通过这项研究，不仅将使用基于患者的评分，还将使用客观评估来量化治疗带来的患者受益。
德国临床试验注册（DRKS）DRKS00000415；Clinicaltrials.gov NCT01037972；EudraCT 2009-017617-29。
