三种常用小儿体外循环回路过滤气态微栓子能力的体外比较。
An in vitro comparison of the ability of three commonly used pediatric cardiopulmonary bypass circuits to filter gaseous microemboli.
作者信息
Melchior Richard W, Rosenthal Tami, Glatz Andrew C
机构信息
Department of Perfusion Services, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
出版信息
Perfusion. 2010 Jul;25(4):255-63; discussion 265-6. doi: 10.1177/0267659110375489. Epub 2010 Jun 21.
BACKGROUND
The purpose of this study was to compare the ability of three commonly used pediatric cardiopulmonary bypass (CPB) circuits to filter gaseous microemboli (GME) in an in vitro model.
METHODS
Devices were tested at different levels of two specific independent variables: volume of air injected (1, 3, 5ml) and percentage of each oxygenator's rated flow (50%, 75%, 100%, 125%). The air-handling ability of each CPB circuit was determined by the Emboli Detection and Classification Quantifier (Luna Innovations Inc., Roanoke,VA).
RESULTS
At all tested conditions, the FX-05 allowed a higher percentage of GME when compared to either one or both of the other two CPB circuits. When comparing oxygenators at similar absolute flow rates, the KIDS D100/D130 CPB circuit performed worse compared to the other two CPB circuits.
CONCLUSIONS
The combination of the Baby RX-05 oxygenator and Capiox AF02 arterial line filter provides the highest level of protection from air emboli in an in vitro investigation.
背景
本研究的目的是在体外模型中比较三种常用的小儿体外循环（CPB）回路过滤气态微栓子（GME）的能力。
方法
在两个特定独立变量的不同水平下对设备进行测试：注入空气量（1、3、5毫升）和每个氧合器额定流量的百分比（50%、75%、100%、125%）。每个CPB回路的空气处理能力由栓子检测和分类定量仪（Luna Innovations Inc.，弗吉尼亚州罗阿诺克）测定。
结果
在所有测试条件下，与其他两个CPB回路中的一个或两个相比，FX - 05允许更高比例的GME通过。在相似的绝对流速下比较氧合器时，KIDS D100/D130 CPB回路比其他两个CPB回路表现更差。
结论
在体外研究中，Baby RX - 05氧合器和Capiox AF02动脉管路过滤器的组合提供了最高水平的空气栓子防护。
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